Several Zn β-diiminate reagents were developed and used to mediate regioselective O-acylation reactions of therapeutic agents with anhydrides. Various prodrugs were obtained in excellent yield and high regioselectivity, including derivatives of rapamycin and paclitaxel. Furthermore, the application of regioselective acylation was extended to one-pot reactions between therapeutics and carboxylic acids with various pendant functional groups. This rapid functionalization strategy will find application in either prodrug synthesis or bioconjugation for drug delivery. This journal is

Original languageEnglish (US)
Pages (from-to)2234-2239
Number of pages6
JournalChemical Science
Issue number7
StatePublished - Jul 2012

ASJC Scopus subject areas

  • Chemistry(all)


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