Zinc chloride-promoted aryl bromide-alkyne cross-coupling reactions at room temperature

Aaron D. Finke, Eric C. Elleby, Michael J. Boyd, Haim Weissman, Jeffrey S. Moore

Research output: Contribution to journalArticlepeer-review

Abstract

(Chemical Equation Presented) Substoichiometric amounts of ZnCl2 promote the room temperature, Pd/P(t-Bu)3-catalyzed cross-coupling of aryl bromides with alkynes. Pd(I) dimer 1 is demonstrated to be a particularly active precatalyst for this reaction. The reaction is general for a wide variety of aryl bromides.

Original languageEnglish (US)
Pages (from-to)8897-8900
Number of pages4
JournalJournal of Organic Chemistry
Volume74
Issue number22
DOIs
StatePublished - Nov 20 2009

ASJC Scopus subject areas

  • Organic Chemistry

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