Zinc chloride-promoted aryl bromide-alkyne cross-coupling reactions at room temperature

Aaron D. Finke; Eric C. Elleby; Michael J. Boyd; Haim Weissman; Jeffrey S. Moore

doi:10.1021/jo902015w

Zinc chloride-promoted aryl bromide-alkyne cross-coupling reactions at room temperature

Aaron D. Finke, Eric C. Elleby, Michael J. Boyd, Haim Weissman, Jeffrey S. Moore

Research output: Contribution to journal › Article › peer-review

Abstract

(Chemical Equation Presented) Substoichiometric amounts of ZnCl₂ promote the room temperature, Pd/P(t-Bu)₃-catalyzed cross-coupling of aryl bromides with alkynes. Pd(I) dimer 1 is demonstrated to be a particularly active precatalyst for this reaction. The reaction is general for a wide variety of aryl bromides.

Original language	English (US)
Pages (from-to)	8897-8900
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	74
Issue number	22
DOIs	https://doi.org/10.1021/jo902015w
State	Published - Nov 20 2009

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Organic Chemistry

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10.1021/jo902015w

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title = "Zinc chloride-promoted aryl bromide-alkyne cross-coupling reactions at room temperature",

abstract = "(Chemical Equation Presented) Substoichiometric amounts of ZnCl2 promote the room temperature, Pd/P(t-Bu)3-catalyzed cross-coupling of aryl bromides with alkynes. Pd(I) dimer 1 is demonstrated to be a particularly active precatalyst for this reaction. The reaction is general for a wide variety of aryl bromides.",

author = "Finke, {Aaron D.} and Elleby, {Eric C.} and Boyd, {Michael J.} and Haim Weissman and Moore, {Jeffrey S.}",

year = "2009",

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language = "English (US)",

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journal = "Journal of Organic Chemistry",

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T1 - Zinc chloride-promoted aryl bromide-alkyne cross-coupling reactions at room temperature

AU - Finke, Aaron D.

AU - Elleby, Eric C.

AU - Boyd, Michael J.

AU - Weissman, Haim

AU - Moore, Jeffrey S.

PY - 2009/11/20

Y1 - 2009/11/20

N2 - (Chemical Equation Presented) Substoichiometric amounts of ZnCl2 promote the room temperature, Pd/P(t-Bu)3-catalyzed cross-coupling of aryl bromides with alkynes. Pd(I) dimer 1 is demonstrated to be a particularly active precatalyst for this reaction. The reaction is general for a wide variety of aryl bromides.

AB - (Chemical Equation Presented) Substoichiometric amounts of ZnCl2 promote the room temperature, Pd/P(t-Bu)3-catalyzed cross-coupling of aryl bromides with alkynes. Pd(I) dimer 1 is demonstrated to be a particularly active precatalyst for this reaction. The reaction is general for a wide variety of aryl bromides.

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Zinc chloride-promoted aryl bromide-alkyne cross-coupling reactions at room temperature

Abstract

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