Young adult born neurons enhance hippocampal dependent performance via influences on bilateral networks

Jia Min Zhuo, Hua An Tseng, Mitul Desai, Mark E. Bucklin, Ali I. Mohammed, Nick Tm Robinson, Edward S. Boyden, Lara M. Rangel, Alan P. Jasanoff, Howard J. Gritton, Xue Han

Research output: Contribution to journalArticlepeer-review

Abstract

Adult neurogenesis supports performance in many hippocampal dependent tasks. Considering the small number of adult-born neurons generated at any given time, it is surprising that this sparse population of cells can substantially influence behavior. Recent studies have demonstrated that heightened excitability and plasticity may be critical for the contribution of young adult-born cells for certain tasks. What is not well understood is how these unique biophysical and synaptic properties may translate to networks that support behavioral function. Here we employed a location discrimination task in mice while using optogenetics to transiently silence adult-born neurons at different ages. We discovered that adult-born neurons promote location discrimination during early stages of development but only if they undergo maturation during task acquisition. Silencing of young adult-born neurons also produced changes extending to the contralateral hippocampus, detectable by both electrophysiology and fMRI measurements, suggesting young neurons may modulate location discrimination through influences on bilateral hippocampal networks.

Original languageEnglish (US)
Article numbere22429
Pages (from-to)25
Number of pages1
JournaleLife
Volume5
Issue numberDECEMBER2016
DOIs
StatePublished - Dec 3 2016
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Young adult born neurons enhance hippocampal dependent performance via influences on bilateral networks'. Together they form a unique fingerprint.

Cite this