Yeast metabolic engineering for carbon dioxide fixation and its application

Soo Rin Kim; Soo Jung Kim; Sun Ki Kim; Seung Oh Seo; Sujeong Park; Jamin Shin; Jeong Sun Kim; Bo Ram Park; Yong Su Jin; Pahn Shick Chang; Yong Cheol Park

doi:10.1016/j.biortech.2021.126349

Yeast metabolic engineering for carbon dioxide fixation and its application

Soo Rin Kim, Soo Jung Kim, Sun Ki Kim, Seung Oh Seo, Sujeong Park, Jamin Shin, Jeong Sun Kim, Bo Ram Park, Yong Su Jin, Pahn Shick Chang, Yong Cheol Park

Research output: Contribution to journal › Review article › peer-review

Abstract

As numerous industrial bioprocesses rely on yeast fermentation, developing CO₂-fixing yeast strains can be an attractive option toward sustainable industrial processes and carbon neutrality. Recent studies have shown that the expression of ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO) in yeasts, such as Saccharomyces cerevisiae and Kluyveromyces marxianus, enables mixotrophic CO₂ fixation and production of biofuels. Also, the expression of a synthetic Calvin-Benson-Bassham (CBB) cycle including RuBisCO in Pichia pastoris enables autotrophic growth on CO₂. This review highlights recent advances in metabolic engineering strategies to enable CO₂ fixation in yeasts. Also, we discuss the potentials of other natural and synthetic metabolic pathways independent of RuBisCO for developing CO₂-fixing yeast strains capable of producing value-added biochemicals.

Original language	English (US)
Article number	126349
Journal	Bioresource Technology
Volume	346
DOIs	https://doi.org/10.1016/j.biortech.2021.126349
State	Published - Feb 2022

Keywords

Calvin-Benson-Bassham (CBB) cycle
Carbon dioxide fixation
Ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO)
Yeast metabolic engineering

ASJC Scopus subject areas

Bioengineering
Waste Management and Disposal
Environmental Engineering
Renewable Energy, Sustainability and the Environment

Online availability

10.1016/j.biortech.2021.126349

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title = "Yeast metabolic engineering for carbon dioxide fixation and its application",

abstract = "As numerous industrial bioprocesses rely on yeast fermentation, developing CO2-fixing yeast strains can be an attractive option toward sustainable industrial processes and carbon neutrality. Recent studies have shown that the expression of ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO) in yeasts, such as Saccharomyces cerevisiae and Kluyveromyces marxianus, enables mixotrophic CO2 fixation and production of biofuels. Also, the expression of a synthetic Calvin-Benson-Bassham (CBB) cycle including RuBisCO in Pichia pastoris enables autotrophic growth on CO2. This review highlights recent advances in metabolic engineering strategies to enable CO2 fixation in yeasts. Also, we discuss the potentials of other natural and synthetic metabolic pathways independent of RuBisCO for developing CO2-fixing yeast strains capable of producing value-added biochemicals.",

keywords = "Calvin-Benson-Bassham (CBB) cycle, Carbon dioxide fixation, Ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO), Yeast metabolic engineering",

author = "{Rin Kim}, Soo and Kim, {Soo Jung} and Kim, {Sun Ki} and Seo, {Seung Oh} and Sujeong Park and Jamin Shin and Kim, {Jeong Sun} and Park, {Bo Ram} and Jin, {Yong Su} and Chang, {Pahn Shick} and Park, {Yong Cheol}",

note = "This work was funded by “ Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ01577001 ; PJ01577002 ; PJ01577003 ; PJ01577004 ; PJ01577005 )” Rural Development Administration, Republic of Korea. Also, it was supported by the National Research Foundation of Korea (NRF) Grants ( 2021R1A2C2005363 ) funded by the Korean Ministry of Science, ICT and Future Planning, and Korea Environmental Industry and Technology Institute (KEITI) grant funded by the Ministry of Environment of Korea.",

year = "2022",

month = feb,

doi = "10.1016/j.biortech.2021.126349",

language = "English (US)",

volume = "346",

journal = "Bioresource Technology",

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T1 - Yeast metabolic engineering for carbon dioxide fixation and its application

AU - Rin Kim, Soo

AU - Kim, Soo Jung

AU - Kim, Sun Ki

AU - Seo, Seung Oh

AU - Park, Sujeong

AU - Shin, Jamin

AU - Kim, Jeong Sun

AU - Park, Bo Ram

AU - Jin, Yong Su

AU - Chang, Pahn Shick

AU - Park, Yong Cheol

N1 - This work was funded by “ Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ01577001 ; PJ01577002 ; PJ01577003 ; PJ01577004 ; PJ01577005 )” Rural Development Administration, Republic of Korea. Also, it was supported by the National Research Foundation of Korea (NRF) Grants ( 2021R1A2C2005363 ) funded by the Korean Ministry of Science, ICT and Future Planning, and Korea Environmental Industry and Technology Institute (KEITI) grant funded by the Ministry of Environment of Korea.

PY - 2022/2

Y1 - 2022/2

N2 - As numerous industrial bioprocesses rely on yeast fermentation, developing CO2-fixing yeast strains can be an attractive option toward sustainable industrial processes and carbon neutrality. Recent studies have shown that the expression of ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO) in yeasts, such as Saccharomyces cerevisiae and Kluyveromyces marxianus, enables mixotrophic CO2 fixation and production of biofuels. Also, the expression of a synthetic Calvin-Benson-Bassham (CBB) cycle including RuBisCO in Pichia pastoris enables autotrophic growth on CO2. This review highlights recent advances in metabolic engineering strategies to enable CO2 fixation in yeasts. Also, we discuss the potentials of other natural and synthetic metabolic pathways independent of RuBisCO for developing CO2-fixing yeast strains capable of producing value-added biochemicals.

AB - As numerous industrial bioprocesses rely on yeast fermentation, developing CO2-fixing yeast strains can be an attractive option toward sustainable industrial processes and carbon neutrality. Recent studies have shown that the expression of ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO) in yeasts, such as Saccharomyces cerevisiae and Kluyveromyces marxianus, enables mixotrophic CO2 fixation and production of biofuels. Also, the expression of a synthetic Calvin-Benson-Bassham (CBB) cycle including RuBisCO in Pichia pastoris enables autotrophic growth on CO2. This review highlights recent advances in metabolic engineering strategies to enable CO2 fixation in yeasts. Also, we discuss the potentials of other natural and synthetic metabolic pathways independent of RuBisCO for developing CO2-fixing yeast strains capable of producing value-added biochemicals.

KW - Calvin-Benson-Bassham (CBB) cycle

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KW - Ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO)

KW - Yeast metabolic engineering

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Yeast metabolic engineering for carbon dioxide fixation and its application

Abstract

Keywords

ASJC Scopus subject areas

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