Xenopus hoxc8 during early development

Chemyong Ko, Hae Moon Chung

Research output: Contribution to journalArticlepeer-review

Abstract

Vertebrate hoxc8 homologous genes have been shown to be involved in the formation of lower thoracic/lumbar vertebrae during early embryonic development. We report the isolation of a Xenopus hoxc8 (Xhoxc8), which shows 94% amino acid sequence identity to the mouse counterpart. Xhoxc8 is initially expressed in a broad region of blastopore lip at gastrular stage; however, at later stages, the region of expression is progressively restricted to the dorsal region caudal to the third somite and to the central trunk region of abdomen. Retinoic acid treatment that caused a severe malformation in antero-posterior axis did not induce any significant change in the spatio-temporal expression pattern of Xhoxc8 mRNA. Antisense RNA injection into 2- or 4-cell stage embryos resulted in a severe malformation in the abdominal structure leading to embryonic death. The results strongly indicate that Xhoxc8 expression is critical for the formation of abdominal structure.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume300
Issue number1
DOIs
StatePublished - 2003
Externally publishedYes

Keywords

  • Abdomen
  • Development
  • Homeobox gene
  • Posterior spinal cord
  • Xenopus laevis
  • hoxc8

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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