Xenopus, An Ideal Vertebrate System for Studies of Eye Development and Regeneration

Jonathan J. Henry, Jason M. Wever, M. Natalia Vergara, Lisa Fukui

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter highlights the Xenopus as the model for studies of eye development and regeneration. Xenopus researchers are now found in nearly every major research institution, and studies using Xenopus have led to tremendous advances in understanding of cell inductive interactions and signaling pathways underlying embryonic pattern formation, cell determination, and organogenesis. More specifically, experimental studies using Xenopus have made significant contributions toward understanding the process of eye development and embryonic lens induction. Though not as proficient as some other amphibians, Xenopus is capable of regenerating certain tissues, including parts of the eye, particularly during larval stages. Furthermore, studies conducted with Xenopus have shed light on the mechanisms underlying these processes. Xenopus offers a tremendous advantage to cell and developmental biologists by providing a ready source of eggs and embryos for research. In captivity, Xenopus remains fertile throughout the year, and mating and egg laying can be stimulated using pituitary extracts or human chorionic gonadotropin.

Original languageEnglish (US)
Title of host publicationAnimal Models in Eye Research
PublisherElsevier Ltd
Pages57-92
Number of pages36
ISBN (Print)9780123741691
DOIs
StatePublished - Dec 1 2008

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Fingerprint Dive into the research topics of 'Xenopus, An Ideal Vertebrate System for Studies of Eye Development and Regeneration'. Together they form a unique fingerprint.

  • Cite this

    Henry, J. J., Wever, J. M., Natalia Vergara, M., & Fukui, L. (2008). Xenopus, An Ideal Vertebrate System for Studies of Eye Development and Regeneration. In Animal Models in Eye Research (pp. 57-92). Elsevier Ltd. https://doi.org/10.1016/B978-0-12-374169-1.00006-0