Xenobiotic biotransformation in livers and lungs of adult black-tailed deer: Comparison with domestic goat and sheep

W. G. Helferich, M. H. Silva, W. T. Flueck, B. D. Hammock, L. R. Shull

Research output: Contribution to journalArticle

Abstract

1. The capacity of liver and lung tissue of black-tailed dear (Odocoileus hemionus columbianus) to biotransform xenobiotics was compared in vitro to the domestic sheep and goat. Donor animals were all females of varying ages. Tissues from the black-tailed deer were collected in the wild. A variety of biotransformation enzymes were measured in both microsomal and cytosolic fractions. 2. Deer liver was lower in total cytochrome P450 concentration, but mono-oxygenase activities were greater compared to sheep and goat. The opposite was true tor the lung. 3. Epoxide hydrolase activities were significantly different in deer vs sheep and goat. 4. In general, both hepatic and pulmonary activities were more similar between sheep and goat than either species compared to the deer, however, the magnitude of the hepatic differences did not exceed 5-fold. 5. Based on these limited results, there is no reason to discredit the sheep or goat as a toxicity testing model for deer.

Original languageEnglish (US)
Pages (from-to)145-149
Number of pages5
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume88
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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