Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion

Jahyun Koo, Sung Bong Kim, Yeon Sik Choi, Zhaoqian Xie, Amay J Bandodkar, Jawad Khalifeh, Ying Yan, Hojun Kim, Maryam Kherad Pezhouh, Karen Doty, Geumbee Lee, Yu-Yu Chen, Seung Min Lee, Dominic D'Andrea, Kimin Jung, KunHyuck Lee, Kan Li, Seongbin Jo, Heling Wang, Jae-Hwan KimJeonghyun Kim, Sung-Geun Choi, Woo Jin Jang, Yong Suk Oh, Inkyu Park, Sung Soo Kwak, Ji-Hyeon Park, Doosun Hong, Xue Feng, Chi-Hwan Lee, Anthony Banks, Cecilia Leal, Hyuck Mo Lee, Yonggang Huang, Colin K Franz, Wilson Z Ray, Matthew MacEwan, Seung-Kyun Kang, John A Rogers

Research output: Contribution to journalArticlepeer-review

Abstract

Implantable drug release platforms that offer wirelessly programmable control over pharmacokinetics have potential in advanced treatment protocols for hormone imbalances, malignant cancers, diabetic conditions, and others. We present a system with this type of functionality in which the constituent materials undergo complete bioresorption to eliminate device load from the patient after completing the final stage of the release process. Here, bioresorbable polyanhydride reservoirs store drugs in defined reservoirs without leakage until wirelessly triggered valve structures open to allow release. These valves operate through an electrochemical mechanism of geometrically accelerated corrosion induced by passage of electrical current from a wireless, bioresorbable power-harvesting unit. Evaluations in cell cultures demonstrate the efficacy of this technology for the treatment of cancerous tissues by release of the drug doxorubicin. Complete in vivo studies of platforms with multiple, independently controlled release events in live-animal models illustrate capabilities for control of blood glucose levels by timed delivery of insulin.

Original languageEnglish (US)
Article numbereabb1093
JournalScience Advances
Volume6
Issue number35
DOIs
StatePublished - Aug 2020

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