TY - JOUR
T1 - Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology
AU - Wu, Yixin
AU - Wu, Mingzheng
AU - Vázquez-Guardado, Abraham
AU - Kim, Joohee
AU - Zhang, Xin
AU - Avila, Raudel
AU - Kim, Jin Tae
AU - Deng, Yujun
AU - Yu, Yongjoon
AU - Melzer, Sarah
AU - Bai, Yun
AU - Yoon, Hyoseo
AU - Meng, Lingzi
AU - Zhang, Yi
AU - Guo, Hexia
AU - Hong, Liu
AU - Kanatzidis, Evangelos E.
AU - Haney, Chad R.
AU - Waters, Emily A.
AU - Banks, Anthony R.
AU - Hu, Ziying
AU - Lie, Ferrona
AU - Chamorro, Leonardo P.
AU - Sabatini, Bernardo L.
AU - Huang, Yonggang
AU - Kozorovitskiy, Yevgenia
AU - Rogers, John A
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - In vivo optogenetics and photopharmacology are two techniques for controlling neuronal activity that have immense potential in neuroscience research. Their applications in tether-free groups of animals have been limited in part due to tools availability. Here, we present a wireless, battery-free, programable multilateral optofluidic platform with user-selected modalities for optogenetics, pharmacology and photopharmacology. This system features mechanically compliant microfluidic and electronic interconnects, capabilities for dynamic control over the rates of drug delivery and real-time programmability, simultaneously for up to 256 separate devices in a single cage environment. Our behavioral experiments demonstrate control of motor behaviors in grouped mice through in vivo optogenetics with co-located gene delivery and controlled photolysis of caged glutamate. These optofluidic systems may expand the scope of wireless techniques to study neural processing in animal models.
AB - In vivo optogenetics and photopharmacology are two techniques for controlling neuronal activity that have immense potential in neuroscience research. Their applications in tether-free groups of animals have been limited in part due to tools availability. Here, we present a wireless, battery-free, programable multilateral optofluidic platform with user-selected modalities for optogenetics, pharmacology and photopharmacology. This system features mechanically compliant microfluidic and electronic interconnects, capabilities for dynamic control over the rates of drug delivery and real-time programmability, simultaneously for up to 256 separate devices in a single cage environment. Our behavioral experiments demonstrate control of motor behaviors in grouped mice through in vivo optogenetics with co-located gene delivery and controlled photolysis of caged glutamate. These optofluidic systems may expand the scope of wireless techniques to study neural processing in animal models.
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U2 - 10.1038/s41467-022-32947-0
DO - 10.1038/s41467-022-32947-0
M3 - Article
C2 - 36137999
AN - SCOPUS:85138352868
SN - 2041-1723
VL - 13
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 5571
ER -