Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry

Hao Zhang, Philipp Gutruf, Kathleen Meacham, Michael C. Montana, Xingyue Zhao, Antonio M. Chiarelli, Abraham Vázquez-Guardado, Aaron Norris, Luyao Lu, Qinglei Guo, Chenkai Xu, Yixin Wu, Hangbo Zhao, Xin Ning, Wubin Bai, Irawati Kandela, Chad R. Haney, Debashis Chanda, Robert W. Gereau, John A. Rogers

Research output: Contribution to journalArticlepeer-review


Monitoring regional tissue oxygenation in animal models and potentially in human subjects can yield insights into the underlying mechanisms of local O 2 -mediated physiological processes and provide diagnostic and therapeutic guidance for relevant disease states. Existing technologies for tissue oxygenation assessments involve some combination of disadvantages in requirements for physical tethers, anesthetics, and special apparatus, often with confounding effects on the natural behaviors of test subjects. This work introduces an entirely wireless and fully implantable platform incorporating (i) microscale optoelectronics for continuous sensing of local hemoglobin dynamics and (ii) advanced designs in continuous, wireless power delivery and data output for tether-free operation. These features support in vivo, highly localized tissue oximetry at sites of interest, including deep brain regions of mice, on untethered, awake animal models. The results create many opportunities for studying various O 2 -mediated processes in naturally behaving subjects, with implications in biomedical research and clinical practice.

Original languageEnglish (US)
Article numbereaaw0873
JournalScience Advances
Issue number3
StatePublished - 2019

ASJC Scopus subject areas

  • General


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