Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo

Jun Xia, Muhammad R. Chatni, Konstantin Maslov, Zijian Guo, Kun Wang, Mark Anastasio, Lihong V. Wang

Research output: Contribution to journalArticlepeer-review

Abstract

We report a novel small-animal whole-body imaging system called ring-shaped confocal photoacoustic computed tomography (RC-PACT). RC-PACT is based on a confocal design of free-space ring-shaped light illumination and 512-element full-ring ultrasonic array signal detection. The free-space light illumination maximizes the light delivery efficiency, and the full-ring signal detection ensures a full two-dimensional view aperture for accurate image reconstruction. Using cylindrically focused array elements, RC-PACT can image a thin cross section with 0.10 to 0.25 mm in-plane resolutions and 1.6 s/frame acquisition time. By translating the mouse along the elevational direction, RC-PACT provides a series of cross-sectional images of the brain, liver, kidneys, and bladder.

Original languageEnglish (US)
Article number050506
JournalJournal of biomedical optics
Volume17
Issue number5
DOIs
StatePublished - May 1 2012
Externally publishedYes

Keywords

  • Anatomic imaging
  • Half-time image reconstruction
  • Photoacoustic computed tomography
  • Small-animal imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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