White light diffraction tomography of unlabeled live cells

Renjie Zhou (Inventor), Mustafa A H Mir (Inventor), Basanta Bhaduri (Inventor), Paul Scott Carney (Inventor), Tae Woo Kim (Inventor), Gabriel Popescu (Inventor), S Darin Babacan (Inventor), Hoa V Pham (Inventor), Lynford L Goddard (Inventor)

Research output: Patent

Abstract

Methods for obtaining a tomographic phase image of a specimen, either in transmission or in scatter. A specimen is illuminated by a temporally incoherent source and light collected in transmission or scattering is used to generate a scattered phase image of the specimen in multiple axial planes. The scattered field is solved for in wavevector space, and a derived instrument function is deconvolved to obtain specimen susceptibility in wavevector space. The specimen susceptibility is transformed to obtain a three-dimensional phase tomogram of the specimen.
Original languageEnglish (US)
U.S. patent number9404857
Filing date6/24/14
StatePublished - Aug 2 2016

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