Where in the world do bacteria experience oxidative stress?

Research output: Contribution to journalReview article

Abstract

Reactive oxygen species – superoxide, hydrogen peroxide and hydroxyl radicals – have long been suspected of constraining bacterial growth in important microbial habitats and indeed of shaping microbial communities. Over recent decades, studies of paradigmatic organisms such as Escherichia coli, Salmonella typhimurium, Bacillus subtilis and Saccharomyces cerevisiae have pinpointed the biomolecules that oxidants can damage and the strategies by which microbes minimize their injuries. What is lacking is a good sense of the circumstances under which oxidative stress actually occurs. In this MiniReview several potential natural sources of oxidative stress are considered: endogenous ROS formation, chemical oxidation of reduced species at oxic–anoxic interfaces, H 2 O 2 production by lactic acid bacteria, the oxidative burst of phagocytes and the redox-cycling of secreted small molecules. While all of these phenomena can be reproduced and verified in the lab, the actual quantification of stress in natural habitats remains lacking – and, therefore, we have a fundamental hole in our understanding of the role that oxidative stress actually plays in the biosphere.

Original languageEnglish (US)
Pages (from-to)521-530
Number of pages10
JournalEnvironmental Microbiology
Volume21
Issue number2
DOIs
StatePublished - Feb 1 2019

Fingerprint

Oxidative Stress
oxidative stress
Bacteria
bacterium
Ecosystem
bacteria
Respiratory Burst
phagocytes
habitat
Salmonella typhimurium
hydroxyl radicals
Phagocytes
hydroxyl radical
Bacillus subtilis
habitats
Oxidants
Salmonella Typhimurium
oxidants
oxidant
Superoxides

ASJC Scopus subject areas

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Where in the world do bacteria experience oxidative stress? / Imlay, James A.

In: Environmental Microbiology, Vol. 21, No. 2, 01.02.2019, p. 521-530.

Research output: Contribution to journalReview article

@article{121825da7fac417a9d5a44f4d7413b2e,
title = "Where in the world do bacteria experience oxidative stress?",
abstract = "Reactive oxygen species – superoxide, hydrogen peroxide and hydroxyl radicals – have long been suspected of constraining bacterial growth in important microbial habitats and indeed of shaping microbial communities. Over recent decades, studies of paradigmatic organisms such as Escherichia coli, Salmonella typhimurium, Bacillus subtilis and Saccharomyces cerevisiae have pinpointed the biomolecules that oxidants can damage and the strategies by which microbes minimize their injuries. What is lacking is a good sense of the circumstances under which oxidative stress actually occurs. In this MiniReview several potential natural sources of oxidative stress are considered: endogenous ROS formation, chemical oxidation of reduced species at oxic–anoxic interfaces, H 2 O 2 production by lactic acid bacteria, the oxidative burst of phagocytes and the redox-cycling of secreted small molecules. While all of these phenomena can be reproduced and verified in the lab, the actual quantification of stress in natural habitats remains lacking – and, therefore, we have a fundamental hole in our understanding of the role that oxidative stress actually plays in the biosphere.",
author = "Imlay, {James A}",
year = "2019",
month = "2",
day = "1",
doi = "10.1111/1462-2920.14445",
language = "English (US)",
volume = "21",
pages = "521--530",
journal = "Environmental Microbiology",
issn = "1462-2912",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Where in the world do bacteria experience oxidative stress?

AU - Imlay, James A

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Reactive oxygen species – superoxide, hydrogen peroxide and hydroxyl radicals – have long been suspected of constraining bacterial growth in important microbial habitats and indeed of shaping microbial communities. Over recent decades, studies of paradigmatic organisms such as Escherichia coli, Salmonella typhimurium, Bacillus subtilis and Saccharomyces cerevisiae have pinpointed the biomolecules that oxidants can damage and the strategies by which microbes minimize their injuries. What is lacking is a good sense of the circumstances under which oxidative stress actually occurs. In this MiniReview several potential natural sources of oxidative stress are considered: endogenous ROS formation, chemical oxidation of reduced species at oxic–anoxic interfaces, H 2 O 2 production by lactic acid bacteria, the oxidative burst of phagocytes and the redox-cycling of secreted small molecules. While all of these phenomena can be reproduced and verified in the lab, the actual quantification of stress in natural habitats remains lacking – and, therefore, we have a fundamental hole in our understanding of the role that oxidative stress actually plays in the biosphere.

AB - Reactive oxygen species – superoxide, hydrogen peroxide and hydroxyl radicals – have long been suspected of constraining bacterial growth in important microbial habitats and indeed of shaping microbial communities. Over recent decades, studies of paradigmatic organisms such as Escherichia coli, Salmonella typhimurium, Bacillus subtilis and Saccharomyces cerevisiae have pinpointed the biomolecules that oxidants can damage and the strategies by which microbes minimize their injuries. What is lacking is a good sense of the circumstances under which oxidative stress actually occurs. In this MiniReview several potential natural sources of oxidative stress are considered: endogenous ROS formation, chemical oxidation of reduced species at oxic–anoxic interfaces, H 2 O 2 production by lactic acid bacteria, the oxidative burst of phagocytes and the redox-cycling of secreted small molecules. While all of these phenomena can be reproduced and verified in the lab, the actual quantification of stress in natural habitats remains lacking – and, therefore, we have a fundamental hole in our understanding of the role that oxidative stress actually plays in the biosphere.

UR - http://www.scopus.com/inward/record.url?scp=85056739417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056739417&partnerID=8YFLogxK

U2 - 10.1111/1462-2920.14445

DO - 10.1111/1462-2920.14445

M3 - Review article

VL - 21

SP - 521

EP - 530

JO - Environmental Microbiology

JF - Environmental Microbiology

SN - 1462-2912

IS - 2

ER -