Water-soluble polypeptides with elongated, charged side chains adopt ultrastable helical conformations

Yanfeng Zhang; Hua Lu; Yao Lin; Jianjun Cheng

doi:10.1021/ma201678r

Water-soluble polypeptides with elongated, charged side chains adopt ultrastable helical conformations

Yanfeng Zhang, Hua Lu, Yao Lin, Jianjun Cheng

Research output: Contribution to journal › Article › peer-review

Abstract

A study was conducted to demonstrate the design and synthesis of a water-soluble α-helical polypeptide electrolytes (αHPE), (poly(γ-(4-aminoethylthiopropoxyl)benzyl-L-glutamate) (PAOBLG-AET) with side chain charge situated 17 σ-bonds away from the peptide backbone. The ring-opening polymerizations (ROPs) of γ-(4-Allyloxylbenzyl)-L-glutamate N-carboxyanhydride (AOB-LGlu-NCA) initiated by hexamethyldisilazane (HMDS) yielded PAOBLGs with controlled molecular weights (MWs) and narrow molecular-weight distributions (MWDs) that were determined by gel permeation chromatography (GPC). The MW and MWD of PAOBLG₁₀ obtained by matrix-assisted laser desorption ionization mass spectrometry (MALDI-TOF MS agreed well with the values obtained by GPC. 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) was also used as a cocatalyst to accelerate the polymerization of AOB-L-Glu-NCA and synthesize higher MW PAOBLGs.

Original language	English (US)
Pages (from-to)	6641-6644
Number of pages	4
Journal	Macromolecules
Volume	44
Issue number	17
DOIs	https://doi.org/10.1021/ma201678r
State	Published - Sep 13 2011

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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title = "Water-soluble polypeptides with elongated, charged side chains adopt ultrastable helical conformations",

abstract = "A study was conducted to demonstrate the design and synthesis of a water-soluble α-helical polypeptide electrolytes (αHPE), (poly(γ-(4-aminoethylthiopropoxyl)benzyl-L-glutamate) (PAOBLG-AET) with side chain charge situated 17 σ-bonds away from the peptide backbone. The ring-opening polymerizations (ROPs) of γ-(4-Allyloxylbenzyl)-L-glutamate N-carboxyanhydride (AOB-LGlu-NCA) initiated by hexamethyldisilazane (HMDS) yielded PAOBLGs with controlled molecular weights (MWs) and narrow molecular-weight distributions (MWDs) that were determined by gel permeation chromatography (GPC). The MW and MWD of PAOBLG10 obtained by matrix-assisted laser desorption ionization mass spectrometry (MALDI-TOF MS agreed well with the values obtained by GPC. 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) was also used as a cocatalyst to accelerate the polymerization of AOB-L-Glu-NCA and synthesize higher MW PAOBLGs.",

author = "Yanfeng Zhang and Hua Lu and Yao Lin and Jianjun Cheng",

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AU - Zhang, Yanfeng

AU - Lu, Hua

AU - Lin, Yao

AU - Cheng, Jianjun

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AB - A study was conducted to demonstrate the design and synthesis of a water-soluble α-helical polypeptide electrolytes (αHPE), (poly(γ-(4-aminoethylthiopropoxyl)benzyl-L-glutamate) (PAOBLG-AET) with side chain charge situated 17 σ-bonds away from the peptide backbone. The ring-opening polymerizations (ROPs) of γ-(4-Allyloxylbenzyl)-L-glutamate N-carboxyanhydride (AOB-LGlu-NCA) initiated by hexamethyldisilazane (HMDS) yielded PAOBLGs with controlled molecular weights (MWs) and narrow molecular-weight distributions (MWDs) that were determined by gel permeation chromatography (GPC). The MW and MWD of PAOBLG10 obtained by matrix-assisted laser desorption ionization mass spectrometry (MALDI-TOF MS agreed well with the values obtained by GPC. 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) was also used as a cocatalyst to accelerate the polymerization of AOB-L-Glu-NCA and synthesize higher MW PAOBLGs.

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