Water-soluble poly(l-serine)s bearing long side-chain with terminal charge groups were synthesized via ring-opening polymerization of O-pentenyl-l-serine N-carboxyanhydride followed by thiol-ene reactions. These side-chain modified poly(l-serine)s adopt β-sheet conformation in aqueous solution with excellent stability against changes in pH and temperature. These water-soluble poly(l-serine) derivatives with charged side-chain functional groups and stable β-sheet conformations showed membrane-penetrating capabilities in different cell lines with low cytotoxicity.
|Original language||English (US)|
|Number of pages||7|
|State||Published - Sep 10 2012|
ASJC Scopus subject areas
- Polymers and Plastics
- Materials Chemistry