Water film thickness-dependent conformation and diffusion of single-strand DNA on poly(ethylene glycol)-silane surface

Jae Hyun Park, N. R. Aluru

Research output: Contribution to journalArticlepeer-review

Abstract

In this paper, we investigate, using molecular dynamics simulations, the conformation and diffusion of longer and shorter single-strand DNA (ssDNA) as a function of water film thickness. While the conformation of the shorter ssDNA is significantly affected and the diffusion is suppressed with reduction in water film thickness, the conformation and diffusion of the longer DNA is not influenced. We explain our observations by considering the competition between stacking interaction of bases and solvation tendency of ssDNA. This paper suggests an approach to control the surface motion of ssDNA in nanoscale water films using film thickness.

Original languageEnglish (US)
Article number123703
JournalApplied Physics Letters
Volume96
Issue number12
DOIs
StatePublished - 2010

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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