Vzg-1/lysophosphatidic acid-receptor involved in peripheral pain transmission

Katarina Renbäck, Makoto Inoue, Akira Yoshida, Fred Nyberg, Hiroshi Ueda

Research output: Contribution to journalArticlepeer-review


The nociception by intraplantar (i.pl.) lysophosphatidic acid (LPA) injection was significantly, but partially blocked when mice received intrathecal (i.t.) antisense oligodeoxynucleotide treatment for the vzg-1 type LPA-receptor. The residual LPA-nociception observed under the condition of pertussis toxin-treatment, which is expected to block presynaptic contribution, was abolished by diphenhydramine (i.pl.), and H1-type histamine receptor antagonist. Taking into account that vzg-1 mRNA was detected in the dorsal root ganglion by RT-PCR method, these findings suggest that the LPA- induced nociception is attributed to the mechanism through vzg-1 receptor on nociceptor endings, and to that through unidentified LPA-receptor on peripheral, possibly mast cells. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)350-354
Number of pages5
JournalMolecular Brain Research
Issue number2
StatePublished - 2000
Externally publishedYes


  • Diphenhydramine (DPH)
  • Dorsal root ganglion (DRG)
  • Histamine
  • Lysophosphatidic acid (LPA)
  • Pertussis toxin (PTX)
  • Polymodal nociceptor
  • Substance P (SP)

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience


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