TY - JOUR
T1 - Vzg-1/lysophosphatidic acid-receptor involved in peripheral pain transmission
AU - Renbäck, Katarina
AU - Inoue, Makoto
AU - Yoshida, Akira
AU - Nyberg, Fred
AU - Ueda, Hiroshi
N1 - Funding Information:
Parts of this study were supported by Grants-in-Aid from the Ministry of Education, Science, Culture, and Sports of Japan, and a research grant from ONO Medical Research Foundation.
PY - 2000
Y1 - 2000
N2 - The nociception by intraplantar (i.pl.) lysophosphatidic acid (LPA) injection was significantly, but partially blocked when mice received intrathecal (i.t.) antisense oligodeoxynucleotide treatment for the vzg-1 type LPA-receptor. The residual LPA-nociception observed under the condition of pertussis toxin-treatment, which is expected to block presynaptic contribution, was abolished by diphenhydramine (i.pl.), and H1-type histamine receptor antagonist. Taking into account that vzg-1 mRNA was detected in the dorsal root ganglion by RT-PCR method, these findings suggest that the LPA- induced nociception is attributed to the mechanism through vzg-1 receptor on nociceptor endings, and to that through unidentified LPA-receptor on peripheral, possibly mast cells. (C) 2000 Elsevier Science B.V.
AB - The nociception by intraplantar (i.pl.) lysophosphatidic acid (LPA) injection was significantly, but partially blocked when mice received intrathecal (i.t.) antisense oligodeoxynucleotide treatment for the vzg-1 type LPA-receptor. The residual LPA-nociception observed under the condition of pertussis toxin-treatment, which is expected to block presynaptic contribution, was abolished by diphenhydramine (i.pl.), and H1-type histamine receptor antagonist. Taking into account that vzg-1 mRNA was detected in the dorsal root ganglion by RT-PCR method, these findings suggest that the LPA- induced nociception is attributed to the mechanism through vzg-1 receptor on nociceptor endings, and to that through unidentified LPA-receptor on peripheral, possibly mast cells. (C) 2000 Elsevier Science B.V.
KW - Diphenhydramine (DPH)
KW - Dorsal root ganglion (DRG)
KW - Histamine
KW - Lysophosphatidic acid (LPA)
KW - Pertussis toxin (PTX)
KW - Polymodal nociceptor
KW - Substance P (SP)
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U2 - 10.1016/S0169-328X(99)00333-2
DO - 10.1016/S0169-328X(99)00333-2
M3 - Article
C2 - 10686359
AN - SCOPUS:0033955969
SN - 0169-328X
VL - 75
SP - 350
EP - 354
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 2
ER -