TY - JOUR
T1 - Voxel-based lesion-parameter mapping
T2 - Identifying the neural correlates of a computational model of word production
AU - Dell, Gary S.
AU - Schwartz, Myrna F.
AU - Nozari, Nazbanou
AU - Faseyitan, Olufunsho
AU - Branch Coslett, H.
N1 - Funding Information:
This research was supported by a grant from the National Institutes of Health’s National Institute for Deafness and Other Communication Disorders: DC000191. The authors thank Daniel Y. Kimberg and Grant W. Walker for contributions to the image analysis and VLSM methods, and Adelyn Brecher and Gabriella Garcia for their role in patient recruitment and testing. We also thank the many research assistants who gathered, scored, and analyzed behavioral data and the research participants and caregivers who made this study possible.
PY - 2013/9
Y1 - 2013/9
N2 - The dual-route interactive two-step model explains the variation in the error patterns of aphasic speakers in picture naming, and word and nonword repetition tasks. The model has three parameters that can vary across individuals: the efficiency of the connections between semantic and lexical representations (s-weight), between lexical and phonological representations (p-weight), and between representations of auditory input and phonological representations (nl-weight). We determined these parameter values in 103 participants with chronic aphasia from left hemisphere stroke whose lesion locations had been determined. Then, using voxel-based lesion-parameter mapping, we mapped the parameters onto the brain, thus determining the neural correlates of the model's mechanisms. The maps and the behavioral findings supported the model's central claim that word repetition is affected by both the p and nl parameters. We propose that these two parameters constitute the model's analogue of the "dorsal stream" component of neurocognitive models of language processing.
AB - The dual-route interactive two-step model explains the variation in the error patterns of aphasic speakers in picture naming, and word and nonword repetition tasks. The model has three parameters that can vary across individuals: the efficiency of the connections between semantic and lexical representations (s-weight), between lexical and phonological representations (p-weight), and between representations of auditory input and phonological representations (nl-weight). We determined these parameter values in 103 participants with chronic aphasia from left hemisphere stroke whose lesion locations had been determined. Then, using voxel-based lesion-parameter mapping, we mapped the parameters onto the brain, thus determining the neural correlates of the model's mechanisms. The maps and the behavioral findings supported the model's central claim that word repetition is affected by both the p and nl parameters. We propose that these two parameters constitute the model's analogue of the "dorsal stream" component of neurocognitive models of language processing.
KW - Aphasia
KW - Computational models
KW - Language production
KW - Voxel-based lesion parameter mapping
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U2 - 10.1016/j.cognition.2013.05.007
DO - 10.1016/j.cognition.2013.05.007
M3 - Article
C2 - 23765000
AN - SCOPUS:84879028469
SN - 0010-0277
VL - 128
SP - 380
EP - 396
JO - Cognition
JF - Cognition
IS - 3
ER -