Voriconazole (UK-109,496) inhibits the growth and alters the morphology of fluconazole-susceptible and -resistant Candida species

Paul Belanger, Cynthia C. Nast, Rutilio Fratti, Homayoon Sanati, Mahmoud Ghannoum

Research output: Contribution to journalArticle

Abstract

The effects of voriconazole on the growth, ultrastructure, and leakage of cytoplasmic materials of Candida species were investigated. MIC data showed that voriconazole was more active than fluconazole. Exposure of yeast to voriconazole caused growth inhibition, cell wall thinning, and cell membrane degradation. Neither cell collapse nor release of cytoplasmic materials was observed in the treated cells.

Original languageEnglish (US)
Pages (from-to)1840-1842
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume41
Issue number8
DOIs
StatePublished - Aug 1997

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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