Voluntary ethanol consumption by female offspring from alcoholic and control Sinclair (S-1) miniature dams.

TY - JOUR

T1 - Voluntary ethanol consumption by female offspring from alcoholic and control Sinclair (S-1) miniature dams.

AU - Tumbleson, M. E.

AU - Dexter, J. D.

AU - Middleton, C. C.

N1 - Funding Information: VOLUNTARY ETHANOL CONSUMPTION BY FEMALE OFFSPRING.FROM ALCOHOLIC AND CONTROL SINCLAIR(S-I) MINIATURE DAMS. M.E. Tumbleson*, J.D. Dexter and C.C. Middleton, Sinclair Comparative Medicine Research Farm, Veterinary Medicine and Medicine, University of Missouri, Columbia, MO 65201. Seven gilts were selected from 6 litters farrowed by alcoholic dams and 9 gilts were selected from 6 litters farrowed by control dams to evaluate ad libitum voluntary ethanol consumption beginning at 12 weeks postweaning. Each of the litters was weaned at 5 weeks postpartum. During the lactation period, the offspring from alcoholic dams received ethanol in the milk; however, from 5 to 17 weeks postpartum, neither control nor alcoholic offspring had access to ethanol. During gestation, alcoholic dams consumed 1.7 g ethanol/kg body welght/day; however, they were allowed access to ethanol only for two 1-hour periods per day. At birth, 5 weeks of age (weaning) and 17 weeks of age (initiation of ad llbltum voluntary ethanol consumption), mean (± SD) body weights were 0.637 ± 0.117, 3.00 ± 0.73 and 7.43 + 1.99 kg, respectively, for offspring from alcoholic dams and 0.767 ± 0.139, 3.88 ± 0.45 and 7.89 ± 2.84 kg, respectively, for offspring from control dams. During 1-5, 6-10, 11-15 and 16-20 weeks on test, gilts from alcoholic dams consumed 6.6, 8.1, 8.5 and 7.1 g ethanol/kg body weight/day, respectively, while gilts from control dams consumed 4.5, 5.7, 6.7 and 7.2 g ethanol/kg body weight/day, respectively. For each of the first 15 weeks on test (17 through 32 weeks postpartum), mean ethanol ~onsumption was greater for alcoholic offspring than for control offspring. Supported in part by a grant from the USBA. Copyright: Medline is the source for the citation and abstract of this record.

PY - 1981

Y1 - 1981

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M3 - Article

C2 - 7198229

AN - SCOPUS:0019739192

VL - 18

SP - 179

EP - 189

JO - Progress in biochemical pharmacology

JF - Progress in biochemical pharmacology

SN - 0079-6085

ER -