Volume-selective fluorescence X-ray Counting - Towards 3-D mapping of naturally occurring trace metals without image reconstruction

J. George, A. Groll, P. J. La Riviére, L. J. Meng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Synchrotron-based X - ray fluorescence computed tomography (XFCT) is a relatively new medical imaging platform that can be used for effectively mapping indicative pathologies of metals such as copper or magnesium in Parkinson's disease and other neurodegenerative disorders [1]. At the present, the sensitivity from these potential in vivo systems is limited due to (a) the intrinsically low interaction probability of the incident X-rays, (b) the limited fluorescence signal from the sample as limited by radiation dose considerations, (c) the relatively inefficient data collection methods currently in use for most of XFCT studies, and (d) the need for high flux such as those from synchrotron X-ray sources. The authors of this work demonstrate a novel method of X-ray fluorescence-based elemental mapping, called volume selective counting, that relies on apertures designed to target a single specifically dimensioned linear segment at a time and X-ray detectors constructed in certain imaging geometries capable of deriving the elemental concentration of these trace metals inside a selected volume without the need for full 3-D image reconstruction. Cross-sectional images and spectra of both a zebra fish and triple glass phantom consisting of copper, bromide, and iron exemplify the viability and practicality of the volume-selective counting method.

Original languageEnglish (US)
Title of host publication2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781479905348
DOIs
StatePublished - Jan 1 2013
Event2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013 - Seoul, Korea, Republic of
Duration: Oct 27 2013Nov 2 2013

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Other

Other2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013
CountryKorea, Republic of
CitySeoul
Period10/27/1311/2/13

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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