Abstract
Well plates with microliter-sized well are routinely used for a wide range of chemical and biological screening experiments. Further downscaling as enabled by microfluidic networks will increase the number of conditions that can be screened with the same amount of often-precious material. Here we present a microfluidic well plate composed of pL-sized wells designed with a novel actuate-to-open (ATO) valving architecture. This reusable well plate can discretely mix 200 pL half-wells in a 4×4 matrix to test for sixteen possible combinations. The device has also been integrated with a photonic crystal biosensor to determine binding events that occur upon mixing.
| Original language | English (US) |
|---|---|
| Title of host publication | 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1897-1899 |
| Number of pages | 3 |
| State | Published - 2008 |
| Event | 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States Duration: Oct 12 2008 → Oct 16 2008 |
Other
| Other | 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 |
|---|---|
| Country/Territory | United States |
| City | San Diego, CA |
| Period | 10/12/08 → 10/16/08 |
Keywords
- Combinatorial chemistry
- Integrated
- Microfluidic
- Valves
ASJC Scopus subject areas
- Chemical Engineering (miscellaneous)
- Bioengineering