Abstract

Well plates with microliter-sized well are routinely used for a wide range of chemical and biological screening experiments. Further downscaling as enabled by microfluidic networks will increase the number of conditions that can be screened with the same amount of often-precious material. Here we present a microfluidic well plate composed of pL-sized wells designed with a novel actuate-to-open (ATO) valving architecture. This reusable well plate can discretely mix 200 pL half-wells in a 4×4 matrix to test for sixteen possible combinations. The device has also been integrated with a photonic crystal biosensor to determine binding events that occur upon mixing.

Original languageEnglish (US)
Title of host publication12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference
PublisherChemical and Biological Microsystems Society
Pages1897-1899
Number of pages3
StatePublished - 2008
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
Duration: Oct 12 2008Oct 16 2008

Other

Other12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
CountryUnited States
CitySan Diego, CA
Period10/12/0810/16/08

Keywords

  • Combinatorial chemistry
  • Integrated
  • Microfluidic
  • Valves

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Schudel, B. R., Choi, C. J., Cunningham, B. T., & Kenis, P. J. A. (2008). VLSI microfluidic well plates for combinatorial chemistry. In 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference (pp. 1897-1899). Chemical and Biological Microsystems Society.