Vitamin B12 catalyzed radical cyclizations of arylalkenes

Chris M. McGinley; Heather A. Relyea; Wilfred A. Van Der Donk

doi:10.1055/s-2005-923588

Vitamin B₁₂ catalyzed radical cyclizations of arylalkenes

Chris M. McGinley, Heather A. Relyea, Wilfred A. Van Der Donk

Research output: Contribution to journal › Article › peer-review

Abstract

The use of vitamin B₁₂ for synthetic organic transformations has been extensively studied. Herein, we report the intramolecular cyclization reaction of a series of arylalkene substrates catalyzed by vitamin B ₁₂. These reactions proceed in good yields in environmentally benign solvents and do not require the use of a toxic heavy metal catalyst. Variation of the reaction pH can predictably alter the product distribution.

Original language	English (US)
Pages (from-to)	211-214
Number of pages	4
Journal	Synlett
Issue number	2
DOIs	https://doi.org/10.1055/s-2005-923588
State	Published - Feb 1 2006

Keywords

Arylalkenes
Radical cyclization
Vitamin B

ASJC Scopus subject areas

Organic Chemistry

Online availability

10.1055/s-2005-923588

Library availability

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Cite this

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abstract = "The use of vitamin B12 for synthetic organic transformations has been extensively studied. Herein, we report the intramolecular cyclization reaction of a series of arylalkene substrates catalyzed by vitamin B 12. These reactions proceed in good yields in environmentally benign solvents and do not require the use of a toxic heavy metal catalyst. Variation of the reaction pH can predictably alter the product distribution.",

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KW - Radical cyclization

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