Vitamin B12 catalyzed radical cyclizations of arylalkenes

Chris M. McGinley, Heather A. Relyea, Wilfred A. Van Der Donk

Research output: Contribution to journalArticlepeer-review


The use of vitamin B12 for synthetic organic transformations has been extensively studied. Herein, we report the intramolecular cyclization reaction of a series of arylalkene substrates catalyzed by vitamin B 12. These reactions proceed in good yields in environmentally benign solvents and do not require the use of a toxic heavy metal catalyst. Variation of the reaction pH can predictably alter the product distribution.

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
Issue number2
StatePublished - Feb 1 2006


  • Arylalkenes
  • Radical cyclization
  • Vitamin B

ASJC Scopus subject areas

  • Organic Chemistry


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