Vitamin A induced hypertriglyceridemia in cholesterol-fed rats

Louis W. Solomon, John W. Erdman

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of level and feeding frequency of retinoic acid (OIC) or retinyl acetate (YL) on the accumulation of lipids in the serum and liver of rats were investigated. Male Sprague-Dawley rats were fed ad libitum 1% cholesterol diets with or without supplemental OIC or YL. Vitamin A-fed groups included (per g of dry diet): 105 μg of OIC or 113 μg YL daily for 28 days, 735 μg OIC or 791 μg YL once each week for 28 days; and 735 or 105 μg OIC on day 1 or 105 μg OIC daily for the week experiment. Daily feeding of OIC or YL increased serum triglyceride concentrations as compared to controls. Several days after removal of OIC or 1 week after removal of supplemental YL from the rat diets, serum triglyceride concentrations returned to basal levels. Cholesterol feeding elevated serum cholesterol as well as hepatic cholesterol, total lipids and vitamin A concentrations. Daily OIC feeding depressed serum and hepatic cholesterol concentrations. These results show that daily supplement of vitamin A increased serum triglycerides and reduced serum and hepatic cholesterol concentrations. Serum and liver alterations were dependent on continued feeding.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalLipids
Volume15
Issue number3
DOIs
StatePublished - Mar 1 1980

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

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