Visualizing chromosome dynamics with GFP

Research output: Contribution to journalReview article

Abstract

By allowing easy labeling of chromosomal and nuclear proteins and the tagging of specific chromosomal regions, the use of green-fluorescent protein (GFP) has provided new and special opportunities for directly observing chromosome dynamics in vivo. Here, we review recent applications of this methodology, focusing particularly on examples where new biology has been learned, or at least sighted. In particular, we focus on active bacterial chromosome segregation, yeast mitosis and centromere dynamics, and large-scale chromatin structure and dynamics within eukaryotic interphase nuclei.

Original languageEnglish (US)
Pages (from-to)250-257
Number of pages8
JournalTrends in Cell Biology
Volume11
Issue number6
DOIs
StatePublished - Jun 2001

ASJC Scopus subject areas

  • Cell Biology

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