Abstract
FLICE-inhibitory proteins (FLIPs) are a family of viral (poxvirus and herpesvirus) and cellular proteins. The hallmark of this family is the presence of tandem death-effector domains (DEDs). Despite this shared motif, each protein possesses different abilities to modulate apoptosis, NF-κB, and interferon regulatory factor 3 (IRF3). These similarities and differences are discussed and highlighted here. The comparative study of FLIPs provides a unique basis to understand virus-host interactions, viral pathogenesis, and cellular regulation of immune system signal transduction pathways.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6539-6541 |
| Number of pages | 3 |
| Journal | Journal of virology |
| Volume | 88 |
| Issue number | 12 |
| DOIs | |
| State | Published - Jun 2014 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology