Viral and cellular FLICE-inhibitory proteins: A comparison of their roles in regulating intrinsic immune responses

Research output: Contribution to journalArticle

Abstract

FLICE-inhibitory proteins (FLIPs) are a family of viral (poxvirus and herpesvirus) and cellular proteins. The hallmark of this family is the presence of tandem death-effector domains (DEDs). Despite this shared motif, each protein possesses different abilities to modulate apoptosis, NF-κB, and interferon regulatory factor 3 (IRF3). These similarities and differences are discussed and highlighted here. The comparative study of FLIPs provides a unique basis to understand virus-host interactions, viral pathogenesis, and cellular regulation of immune system signal transduction pathways.

Original languageEnglish (US)
Pages (from-to)6539-6541
Number of pages3
JournalJournal of virology
Volume88
Issue number12
DOIs
StatePublished - Jun 2014

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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