TY - JOUR
T1 - Vibrational Echo Studies of Heme-Protein Dynamics
AU - Fayer, M. D.
AU - Dlott, Dana D.
PY - 1997
Y1 - 1997
N2 - The first picosecond infrared vibrational echo experiments on a protein, myoglobin-CO, are described. The experiments, performed over a temperature range of 50-300K, with native and mutant myoglobin in different solvents, provide information about protein dynamics occurring on the 10-12-10-10 s time scales, which influence the vibrational transition of the CO ligand bound to the active site. The experiments reveal the existence of a protein energy landscape with a relatively flat distribution of energies between conformational minima, which interconvert via tunneling at lower temperature and by activated processes at ambient temperature.
AB - The first picosecond infrared vibrational echo experiments on a protein, myoglobin-CO, are described. The experiments, performed over a temperature range of 50-300K, with native and mutant myoglobin in different solvents, provide information about protein dynamics occurring on the 10-12-10-10 s time scales, which influence the vibrational transition of the CO ligand bound to the active site. The experiments reveal the existence of a protein energy landscape with a relatively flat distribution of energies between conformational minima, which interconvert via tunneling at lower temperature and by activated processes at ambient temperature.
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U2 - 10.1021/bk-1997-0676.ch023
DO - 10.1021/bk-1997-0676.ch023
M3 - Article
AN - SCOPUS:0347137387
SN - 0097-6156
VL - 676
SP - 324
EP - 337
JO - ACS Symposium Series
JF - ACS Symposium Series
ER -