Versatile Target-Guided Screen for Discovering Bidirectional Transcription Inhibitors of a Trinucleotide Repeat Disease

Keyphrases

• Transcription Inhibitors 100%
• Trinucleotide Repeat Diseases 100%
• Target-guided 100%
• Bidirectional Transcription 100%
• Nucleic Acids 50%
• MALDI-TOF Mass Spectrometry 50%
• Nucleotide Sequence 50%
• Myotonic Dystrophy 50%
• Click-iT 50%
• Disease-associated 50%
• Screening Method 50%
• Form-stable 50%
• RNA Transcripts 50%
• IC50 Value 50%
• Template-assisted 50%
• CTG Repeat 50%
• Binding Ligand 50%
• Fragment Library 50%
• In Vitro Transcription 50%
• Hairpin Structure 50%
• Hit Compound 50%
• Nucleic Acid Binding 50%
• Repeat-associated non-ATG Translation 50%
• Screen Use 50%
• Fragment-based 50%
• Azide-alkyne 50%

Biochemistry, Genetics and Molecular Biology

• Transcription 100%
• Trinucleotide Repeat Expansion 100%
• DNA Template 66%
• Click 66%
• RNA 33%
• Nucleic Acid 33%
• Nucleotide Sequence 33%
• Time-of-Flight Mass Spectrometry 33%
• Matrix-Assisted Laser Desorption-Ionization 33%
• IC50 33%
• Nucleic Acid Binding 33%