Versatile photonic crystal fiber-enabled source for multi-modality biophotonic imaging beyond conventional multiphoton microscopy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In a typical multiphoton microscope, the majority of the laser power from the near-IR pulsed source is thrown away in order to prevent photo-damage on biological samples. It is thus desirable to convert this wasted power into other wavelengths through nonlinear fiber optics to accommodate imaging modalities beyond conventional multiphoton microscopy. Here we present a prototypical source that accommodates the requirements for laser scanning confocal microscopy, fluorescence lifetime imaging microscopy, stimulated emission microscopy, coherent anti-Stokes Raman microscopy/spectroscopy, transient absorption microscopy, and optical coherence tomography/microscopy. Such versatile source consists of dispersion-engineered photonic crystal fibers simultaneously pumped by a compact ∼1040 nm ultrafast ytterbium laser.

Original languageEnglish (US)
Title of host publicationMultiphoton Microscopy in the Biomedical Sciences X
DOIs
StatePublished - May 7 2010
EventMultiphoton Microscopy in the Biomedical Sciences X - San Francisco, CA, United States
Duration: Jan 24 2010Jan 26 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7569
ISSN (Print)1605-7422

Other

OtherMultiphoton Microscopy in the Biomedical Sciences X
CountryUnited States
CitySan Francisco, CA
Period1/24/101/26/10

Keywords

  • Femtosecond laser
  • Multiphoton microscopy
  • Nonlinear fiber optics
  • Photonic crystal fiber

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Tu, H., & Boppart, S. A. (2010). Versatile photonic crystal fiber-enabled source for multi-modality biophotonic imaging beyond conventional multiphoton microscopy. In Multiphoton Microscopy in the Biomedical Sciences X [75692D] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7569). https://doi.org/10.1117/12.841298