Vascular-targeted molecular imaging using functionalized polymerized vesicles

King C.P. Li, Mark D. Bednarski

Research output: Contribution to journalReview article

Abstract

In this review we will discuss the use of multivalent polymerized vesicles (PVs) combined with magnetic resonance imaging (MRI) and gamma scintigraphy to image expression of vascular molecular receptors in vivo. Specifically, we will present our data on the use of this technology to design imaging agents toward specific vascular receptors in both a mouse and rabbit tumor model and in the EAE mouse, a model for human multiple sclerosis (MS). Examples will be shown where the in vivo specificity of the targeted molecular imaging agents was validated in the animal models. Since the PVs are designed to carry either contrast or therapeutic agents or both, we can potentially use vascular-targeted imaging for selecting patients and guiding vascular-targeted therapies in these patients. Using this combined vascular-targeted imaging and therapy approach, personalized treatment can potentially be delivered, maximizing efficacy and minimizing side effects.

Original languageEnglish (US)
Pages (from-to)388-393
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume16
Issue number4
DOIs
StatePublished - Oct 1 2002
Externally publishedYes

Keywords

  • Angiogenesis
  • Contrast media
  • Endothelium
  • Integrin
  • Molecular imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Vascular-targeted molecular imaging using functionalized polymerized vesicles'. Together they form a unique fingerprint.

  • Cite this