Vascular elasticity from regional displacement estimates

Jerome J. Mai, Fermin A. Lupotti, Michael F. Insana

Research output: Contribution to journalArticlepeer-review

Abstract

A recently-developed ultrasonic technique for measuring elastic properties of vascular tissue is evaluated using computer simulations, phantom and in vivo human measurements. A time sequence of displacement images is measured over the cardiac cycle to describe the spatial and temporal patterns of deformation surrounding arteries. This information is combined with a mathematical model to estimate an elastic modulus. Computer simulations of ultrasonic echo data from deformed tissues are analyzed to define a signal processing approach. Measurements in flow phantoms, with and without vessel-simulating channel walls, provide an assessment of the accuracy and precision of this technique for vascular elasticity measurements. Finally, preliminary results for the stiffness index (β) in a study group of healthy human volunteers are compared with previously reported data. We find that careful measurement technique is required to control measurement variability.

Original languageEnglish (US)
Pages (from-to)171-192
Number of pages22
JournalUltrasonic Imaging
Volume25
Issue number3
DOIs
StatePublished - Jul 1 2003
Externally publishedYes

Keywords

  • Brachial artery
  • Displacement estimates
  • Phantom elasticity
  • Stiffness index
  • Ultrasound
  • Vascular compliance

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Acoustics and Ultrasonics

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