Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people

Iole Tomassini Barbarossa; M. Hakan Ozdener; Melania; Latisha Love-Gregory; Makedonka Mitreva; Nada A. Abumrad; M. Yanina Pepino

doi:10.1016/j.bbr.2017.05.015

Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people

Iole Tomassini Barbarossa, M. Hakan Ozdener, Melania, Latisha Love-Gregory, Makedonka Mitreva, Nada A. Abumrad, M. Yanina Pepino

Research output: Contribution to journal › Article › peer-review

Abstract

Deeper understanding of signaling mechanisms underlying bitterness perception in people is essential for designing novel and effective bitter blockers, which could enhance nutrition and compliance with orally administered bitter-tasting drugs. Here we show that variability in a human odorant-binding protein gene, OBPIIa, associates with individual differences in bitterness perception of fat (oleic acid) and of a prototypical bitter stimulus, 6-n-propylthiouracil (PROP), suggesting a novel olfactory role in the modulation of bitterness sensitivity.

Original language	English (US)
Pages (from-to)	200-204
Number of pages	5
Journal	Behavioural Brain Research
Volume	329
DOIs	https://doi.org/10.1016/j.bbr.2017.05.015
State	Published - Jun 30 2017

Keywords

Bitter taste
Individual differences
Olfaction
Olfactory binding protein
PROP
Smell

ASJC Scopus subject areas

Behavioral Neuroscience

Online availability

10.1016/j.bbr.2017.05.015

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title = "Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people",

abstract = "Deeper understanding of signaling mechanisms underlying bitterness perception in people is essential for designing novel and effective bitter blockers, which could enhance nutrition and compliance with orally administered bitter-tasting drugs. Here we show that variability in a human odorant-binding protein gene, OBPIIa, associates with individual differences in bitterness perception of fat (oleic acid) and of a prototypical bitter stimulus, 6-n-propylthiouracil (PROP), suggesting a novel olfactory role in the modulation of bitterness sensitivity.",

keywords = "Bitter taste, Individual differences, Olfaction, Olfactory binding protein, PROP, Smell",

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AU - Tomassini Barbarossa, Iole

AU - Ozdener, M. Hakan

AU - Melania,

AU - Love-Gregory, Latisha

AU - Mitreva, Makedonka

AU - Abumrad, Nada A.

AU - Pepino, M. Yanina

PY - 2017/6/30

Y1 - 2017/6/30

N2 - Deeper understanding of signaling mechanisms underlying bitterness perception in people is essential for designing novel and effective bitter blockers, which could enhance nutrition and compliance with orally administered bitter-tasting drugs. Here we show that variability in a human odorant-binding protein gene, OBPIIa, associates with individual differences in bitterness perception of fat (oleic acid) and of a prototypical bitter stimulus, 6-n-propylthiouracil (PROP), suggesting a novel olfactory role in the modulation of bitterness sensitivity.

AB - Deeper understanding of signaling mechanisms underlying bitterness perception in people is essential for designing novel and effective bitter blockers, which could enhance nutrition and compliance with orally administered bitter-tasting drugs. Here we show that variability in a human odorant-binding protein gene, OBPIIa, associates with individual differences in bitterness perception of fat (oleic acid) and of a prototypical bitter stimulus, 6-n-propylthiouracil (PROP), suggesting a novel olfactory role in the modulation of bitterness sensitivity.

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KW - Individual differences

KW - Olfaction

KW - Olfactory binding protein

KW - PROP

KW - Smell

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Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people

Abstract

Keywords

ASJC Scopus subject areas

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