Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people

Iole Tomassini Barbarossa, M. Hakan Ozdener, Melania, Latisha Love-Gregory, Makedonka Mitreva, Nada A. Abumrad, M. Yanina Pepino

Research output: Contribution to journalArticle

Abstract

Deeper understanding of signaling mechanisms underlying bitterness perception in people is essential for designing novel and effective bitter blockers, which could enhance nutrition and compliance with orally administered bitter-tasting drugs. Here we show that variability in a human odorant-binding protein gene, OBPIIa, associates with individual differences in bitterness perception of fat (oleic acid) and of a prototypical bitter stimulus, 6-n-propylthiouracil (PROP), suggesting a novel olfactory role in the modulation of bitterness sensitivity.

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalBehavioural Brain Research
Volume329
DOIs
StatePublished - Jun 30 2017

Keywords

  • Bitter taste
  • Individual differences
  • Olfaction
  • Olfactory binding protein
  • PROP
  • Smell

ASJC Scopus subject areas

  • Behavioral Neuroscience

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    Tomassini Barbarossa, I., Ozdener, M. H., Melania, Love-Gregory, L., Mitreva, M., Abumrad, N. A., & Pepino, M. Y. (2017). Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people. Behavioural Brain Research, 329, 200-204. https://doi.org/10.1016/j.bbr.2017.05.015