Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae

Stephan Lane, Jia Dong, Yong Su Jin

Research output: Contribution to journalReview articlepeer-review


The substantial research efforts into lignocellulosic biofuels have generated an abundance of valuable knowledge and technologies for metabolic engineering. In particular, these investments have led to a vast growth in proficiency of engineering the yeast Saccharomyces cerevisiae for consuming lignocellulosic sugars, enabling the simultaneous assimilation of multiple carbon sources, and producing a large variety of value-added products by introduction of heterologous metabolic pathways. While microbial conversion of cellulosic sugars into large-volume low-value biofuels is not currently economically feasible, there may still be opportunities to produce other value-added chemicals as regulation of cellulosic sugar metabolism is quite different from glucose metabolism. This review summarizes these recent advances with an emphasis on employing engineered yeast for the bioconversion of lignocellulosic sugars into a variety of non-ethanol value-added products.

Original languageEnglish (US)
Pages (from-to)380-394
Number of pages15
JournalBioresource Technology
StatePublished - Jul 2018


  • Fermentation
  • Lignocellulosic biofuels
  • Metabolic engineering
  • Saccharomyces cerevisiae
  • Synthetic biology

ASJC Scopus subject areas

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal


Dive into the research topics of 'Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae'. Together they form a unique fingerprint.

Cite this