Validation of the Bayley Infant Neurodevelopmental Screener among HIV-Exposed Infants in Rural South Africa

Violeta J. Rodriguez, Miriam Zegarac, Dominique L. La Barrie, Manasi Soni Parrish, Gladys Matseke, Karl Peltzer, Deborah L. Jones

Research output: Contribution to journalArticlepeer-review


Introduction:Screening for developmental delays during critical periods of infant development is essential for early detection and intervention. Among high-risk infants in resource-limited settings, including those who are HIV exposed, there is a greater need for screening. This study expanded on previous analyses of the Bayley Infant Neurodevelopmental Screener (BINS) by providing psychometric properties to evaluate the appropriateness of using the BINS in a sample of HIV-exposed infants in rural South Africa.Method:A total of 160 mothers with HIV, their infants, and their male partners were recruited. The BINS was administered to the infants, and their weights were recorded. Mothers completed measures of depression, intimate partner violence, male involvement, and adherence. Male partners reported their own involvement in perinatal care.Results:Results demonstrated support for a 5-factor structure consistent with previous transcultural adaptations of the BINS, demonstrating construct validity, and adequate reliability. Convergent validity was partially supported, as shown by associations with intimate partner violence and male involvement as reported by men and women and maternal adherence, although not with birth weight or maternal depression. The BINS showed adequate discriminating power, with only a few low-performing items.Conclusion:In rural South Africa, a resource-limited setting, the BINS seems to be an adequate screening tool for developmental delays in children that may be used to identify those in need of intervention. Considering the high prevalence of delays identified in this study, antiretroviral therapy-exposed and HIV-exposed infants may benefit from further assessment to determine a need for intervention in community-based clinics.

Original languageEnglish (US)
Pages (from-to)507-516
Number of pages10
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number4
StatePublished - Dec 1 2020
Externally publishedYes


  • HIV-exposed infants
  • Neurodevelopmental screener
  • South Africa

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)


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