Validating the cancer diagnosis potential of mid-infrared spectroscopic imaging

F. Nell Pounder, Rohith K. Reddy, Michael J. Walsh, Rohit Bhargava

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Histologic diagnosis is the gold standard for evaluating the presence and severity of most cancers. Unfortunately, the manual nature of histologic recognition leads to low throughput and errors. Here, we report on the evaluation of an automated means to accurate histologic recognition using mid-infrared spectroscopic imaging. The method does not need dyes or probes and dispenses with human input but relies on computational approaches to provide decisions. Hence, the results must be rigorously validated. We present here a validation of two-class models for pixel-level histologic segmentation and pathologic classification by spatial polling for breast carcinoma. We also discuss optimization of spectral resolution and instrumentation for clinical translation.

Original languageEnglish (US)
Title of host publicationOptical Diagnostics and Sensing IX
DOIs
StatePublished - Jun 15 2009
EventOptical Diagnostics and Sensing IX - San Jose, CA, United States
Duration: Jan 26 2009Jan 27 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7186
ISSN (Print)1605-7422

Other

OtherOptical Diagnostics and Sensing IX
CountryUnited States
CitySan Jose, CA
Period1/26/091/27/09

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Keywords

  • Breast
  • Cancer
  • chemical imaging
  • Diagnosis
  • Fourier transform infrared spectroscopy
  • FT-IR
  • Imaging
  • Mid-IR, FPA
  • Spatial polling
  • Spectral resolution

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Pounder, F. N., Reddy, R. K., Walsh, M. J., & Bhargava, R. (2009). Validating the cancer diagnosis potential of mid-infrared spectroscopic imaging. In Optical Diagnostics and Sensing IX [71860f] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7186). https://doi.org/10.1117/12.810122