Using the Micropublications ontology and the Open Annotation Data Model to represent evidence within a drug-drug interaction knowledge base

Jodi Schneider, Paolo Ciccarese, Tim Clark, Richard D. Boyce

Research output: Contribution to journalConference articlepeer-review

Abstract

Semantic web technologies can support the rapid and trans- parent validation of scientific claims by interconnecting the assumptions and evidence used to support or challenge assertions. One important application domain is medication safety, where more efficient acquisition, representation, and synthesis of evidence about potential drug-drug interactions is needed. Potential drug-drug interactions (PDDIs), defined as two or more drugs for which an interaction is known to be possible, are a significant source of preventable drug-related harm. The combination of poor quality evidence on PDDIs, and a general lack of PDDI knowledge by prescribers, results in many thousands of preventable medication errors each year. While many sources of PDDI evidence exist to help improve prescriber knowledge, they are not concordant in their coverage, accuracy, and agreement. The goal of this project is to research and develop core components of a new model that supports more efficient acquisition, representation, and synthesis of evidence about potential drug-drug interactions. Two Semantic Web models-the Micropublications Ontology and the Open Annotation Data Model-have great potential to provide linkages from PDDI assertions to their supporting evidence: statements in source documents that mention data, materials, and methods. In this paper, we describe the context and goals of our work, propose competency questions for a dynamic PDDI evidence base, outline our new knowledge representation model for PDDIs, and discuss the challenges and potential of our approach.

Original languageEnglish (US)
Pages (from-to)60-70
Number of pages11
JournalCEUR Workshop Proceedings
Volume1282
StatePublished - 2014
Externally publishedYes
Event4th Workshop on Linked Science: Making Sense Out of Data, LISC 2014, Collocated with the 13th International Semantic Web Conference, ISWC 2014 - Riva del Garda, Trentino, Italy
Duration: Oct 19 2014 → …

Keywords

  • Drug-drug interactions
  • Evidence bases
  • Knowledge bases
  • Linked data
  • Micropublications
  • Open annotation data model

ASJC Scopus subject areas

  • Computer Science(all)

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