Using passive cavitation detection to observe postexcitation response of ultrasound contrast agents

Daniel A. King, Mathieu Santin, Michael J. Malloy, Alayna C. Roberts, Alexander Haak, Josquin Foiret, Sylvain Haupert, Sara Jafari, Lori Bridal, William D. O'Brien

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Passive cavitation detection was used to improve the experimental characterization of single ultrasound contrast agent microbubble responses to short, large amplitude pulses. Two situations were examined: isolated microbubbles in an unconstrained environment, and isolated microbubbles flowing through a tube. The microbubbles were categorized according to a classification scheme based on the presence or absence of postexcitation signals, which are secondary broadband spikes that may follow the principle oscillation of the ultrasound contrast agent in response to an insonifying pulse. Experiments were conducted for different frequencies, peak rarefactional pressures, flow rates, and types of microbubble. Postexcitation activity was found to increase as frequency decreased, acoustic pressure increased, and flow rate increased. Additionally, lipid-shelled microbubbles were found to exhibit greater postexcitation at lower acoustic pressure thresholds than albumin-shelled microbubbles.

Original languageEnglish (US)
Title of host publication2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
PublisherInstitute of Electrical and Electronics Engineers Inc.
Number of pages4
ISBN (Print)9781424443895
StatePublished - 2009
Event2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy
Duration: Sep 20 2009Sep 23 2009

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117


Other2009 IEEE International Ultrasonics Symposium, IUS 2009


  • Flow rate
  • Inertial cavitation
  • Microbubbles
  • Passive cavitation detection
  • Postexcitation

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


Dive into the research topics of 'Using passive cavitation detection to observe postexcitation response of ultrasound contrast agents'. Together they form a unique fingerprint.

Cite this