@inproceedings{8bdd19b599614583bb8887e85858a489,
title = "Using microfluidics and mass spectrometry to study peptide release in neurons",
abstract = "We present here two microfluidic devices designed to create and maintain a neuronal network and characterize its response to chemical stimulation using mass spectrometry. The first microfluidic device is composed of microvalve controlled PDMS channels that are adhered to an octadecyltrichlorosilane functionalized silicon wafer. This surface functionalization provides for neuropeptide releasate collection through hydrophobic interactions. Following collection, the adsorbed peptides are interrogated on-chip using mass spectrometry imaging. A second microfluidic device consists of a main channel with two stimulation channels that provides for off-line collection and detection of peptide releasates with precise control over chemical stimulations applied to cultured neurons.",
keywords = "Mass spectrometry, Microfluidics, Microvalves, Neurons",
author = "Croushore, {C. A.} and Lee, {C. Y.} and M. Zhong and Sweedler, {Jonathan V}",
year = "2011",
month = dec,
day = "1",
language = "English (US)",
isbn = "9781618395955",
series = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
pages = "858--860",
booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
note = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",
}