Using an Integer Programming Model to Determine the Price of Combination Vaccines for Childhood Immunization

Edward C. Sewell; Sheldon H. Jacobson

doi:10.1023/A:1022955111568

Using an Integer Programming Model to Determine the Price of Combination Vaccines for Childhood Immunization

Research output: Contribution to journal › Article › peer-review

Abstract

The Recommended Childhood Immunization Schedule has become sufficiently crowded that the prospect of adding additional vaccines to this schedule may not be well received by either health-care providers or parents/guardians. This has encouraged vaccine manufacturers to develop combination vaccines that can permit new vaccines to be added to the schedule without requiring children to be exposed to an unacceptable number of injections during a single clinic visit. This paper develops an integer programming model to assess the economic premium that exists in having combination vaccines available. The results of this study suggest that combination vaccines provide a cost effective alternative to individual vaccines and that further developments and innovations in this area by vaccine manufacturers can provide significant economic and societal benefits.

Original language	English (US)
Pages (from-to)	261-284
Number of pages	24
Journal	Annals of Operations Research
Volume	119
Issue number	1-4
DOIs	https://doi.org/10.1023/A:1022955111568
State	Published - Mar 2003

Keywords

Combination vaccines
Economic analysis
Integer programming
Pediatric immunization
Reverse engineering

ASJC Scopus subject areas

General Decision Sciences
Management Science and Operations Research

Online availability

10.1023/A:1022955111568

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title = "Using an Integer Programming Model to Determine the Price of Combination Vaccines for Childhood Immunization",

abstract = "The Recommended Childhood Immunization Schedule has become sufficiently crowded that the prospect of adding additional vaccines to this schedule may not be well received by either health-care providers or parents/guardians. This has encouraged vaccine manufacturers to develop combination vaccines that can permit new vaccines to be added to the schedule without requiring children to be exposed to an unacceptable number of injections during a single clinic visit. This paper develops an integer programming model to assess the economic premium that exists in having combination vaccines available. The results of this study suggest that combination vaccines provide a cost effective alternative to individual vaccines and that further developments and innovations in this area by vaccine manufacturers can provide significant economic and societal benefits.",

keywords = "Combination vaccines, Economic analysis, Integer programming, Pediatric immunization, Reverse engineering",

author = "Sewell, {Edward C.} and Jacobson, {Sheldon H.}",

note = "Funding Information: The authors would like to thank the special issue editor, Dr. Eva K. Lee, the Associate Editor, and two anonymous referees for their insightful comments and suggestions. The authors would also like to express their thanks and gratitude to Dr. Bruce G. Weniger of the Centers for Disease Control and Prevention for his helpful comments and feedback on this paper, for providing access to data, as well as for his overall long-term support for this line of research. The second author is supported in part by the Air Force Office of Scientific Research (F49620-01-1-0007). This research is supported by the National Science Foundation (OMI-0222554, OMI-0222597).",

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language = "English (US)",

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AU - Sewell, Edward C.

AU - Jacobson, Sheldon H.

N1 - Funding Information: The authors would like to thank the special issue editor, Dr. Eva K. Lee, the Associate Editor, and two anonymous referees for their insightful comments and suggestions. The authors would also like to express their thanks and gratitude to Dr. Bruce G. Weniger of the Centers for Disease Control and Prevention for his helpful comments and feedback on this paper, for providing access to data, as well as for his overall long-term support for this line of research. The second author is supported in part by the Air Force Office of Scientific Research (F49620-01-1-0007). This research is supported by the National Science Foundation (OMI-0222554, OMI-0222597).

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N2 - The Recommended Childhood Immunization Schedule has become sufficiently crowded that the prospect of adding additional vaccines to this schedule may not be well received by either health-care providers or parents/guardians. This has encouraged vaccine manufacturers to develop combination vaccines that can permit new vaccines to be added to the schedule without requiring children to be exposed to an unacceptable number of injections during a single clinic visit. This paper develops an integer programming model to assess the economic premium that exists in having combination vaccines available. The results of this study suggest that combination vaccines provide a cost effective alternative to individual vaccines and that further developments and innovations in this area by vaccine manufacturers can provide significant economic and societal benefits.

AB - The Recommended Childhood Immunization Schedule has become sufficiently crowded that the prospect of adding additional vaccines to this schedule may not be well received by either health-care providers or parents/guardians. This has encouraged vaccine manufacturers to develop combination vaccines that can permit new vaccines to be added to the schedule without requiring children to be exposed to an unacceptable number of injections during a single clinic visit. This paper develops an integer programming model to assess the economic premium that exists in having combination vaccines available. The results of this study suggest that combination vaccines provide a cost effective alternative to individual vaccines and that further developments and innovations in this area by vaccine manufacturers can provide significant economic and societal benefits.

KW - Combination vaccines

KW - Economic analysis

KW - Integer programming

KW - Pediatric immunization

KW - Reverse engineering

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Using an Integer Programming Model to Determine the Price of Combination Vaccines for Childhood Immunization

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