Using an Integer Programming Model to Determine the Price of Combination Vaccines for Childhood Immunization

Edward C. Sewell, Sheldon H. Jacobson

Research output: Contribution to journalArticle

Abstract

The Recommended Childhood Immunization Schedule has become sufficiently crowded that the prospect of adding additional vaccines to this schedule may not be well received by either health-care providers or parents/guardians. This has encouraged vaccine manufacturers to develop combination vaccines that can permit new vaccines to be added to the schedule without requiring children to be exposed to an unacceptable number of injections during a single clinic visit. This paper develops an integer programming model to assess the economic premium that exists in having combination vaccines available. The results of this study suggest that combination vaccines provide a cost effective alternative to individual vaccines and that further developments and innovations in this area by vaccine manufacturers can provide significant economic and societal benefits.

Original languageEnglish (US)
Pages (from-to)261-284
Number of pages24
JournalAnnals of Operations Research
Volume119
Issue number1-4
DOIs
StatePublished - Mar 1 2003

Keywords

  • Combination vaccines
  • Economic analysis
  • Integer programming
  • Pediatric immunization
  • Reverse engineering

ASJC Scopus subject areas

  • Decision Sciences(all)
  • Management Science and Operations Research

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