Use of quantitative ultrasound to detect temperature variations in biological phantoms due to heating

Goutam Ghoshal, Michael L. Oelze

Research output: Chapter in Book/Report/Conference proceedingConference contribution


High intensity focused ultrasound (HIFU) is a noninvasive technique that has great potential for improving thermal therapies. To target specified regions accurately for treatment, a robust imaging technique is required to monitor HIFU application. Therefore, the development of an ultrasonic imaging technique for monitoring HIFU treatment is highly medically significant. Quantitative ultrasound (QUS) is a novel imaging technique that may improve monitoring of HIFU treatment by quantifying tissue changes. Ultrasonic backscatter experiments were performed on two types of phantoms to understand the variations in QUS parameters with increases in temperature from 36 to 50°C. The phantoms were biological phantoms made of agar and containing either mouse mammary carcinoma cells (4T1) or chinese hamster ovary cells (CHO) as scatterers. All scatterers were uniformly distributed spatially at random throughout the phantoms. Sound speed and attenuation were estimated in the phantoms versus temperature using insertion loss methods. Two parameters were estimated from the backscatter coefficient (effective scatterer diameter (ESD) and effective acoustic concentration (EAC)) and two parameters were estimated from the envelope statistics (κ parameter and μ parameter) of the backscattered echoes versus temperature. The results of this study suggest that QUS has the potential to be used for noninvasive monitoring of temperature changes in tissues.

Original languageEnglish (US)
Title of host publication2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
PublisherInstitute of Electrical and Electronics Engineers Inc.
Number of pages4
ISBN (Print)9781424443895
StatePublished - 2009
Event2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy
Duration: Sep 20 2009Sep 23 2009

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117


Other2009 IEEE International Ultrasonics Symposium, IUS 2009

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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