Use of Pig as a Model for Mesenchymal Stem Cell Therapies for Bone Regeneration

Marcello Rubessa, Kathryn Polkoff, Massimo Bionaz, Elisa Monaco, Derek J. Milner, Scott J. Holllister, Michael S. Goldwasser, Matthew B Wheeler

Research output: Contribution to journalReview article

Abstract

Bone is a plastic tissue with a large healing capability. However, extensive bone loss due to disease or trauma requires extreme therapy such as bone grafting or tissue-engineering applications. Presently, bone grafting is the gold standard for bone repair, but presents serious limitations including donor site morbidity, rejection, and limited tissue regeneration. The use of stem cells appears to be a means to overcome such limitations. Bone marrow mesenchymal stem cells (BMSC) have been the choice thus far for stem cell therapy for bone regeneration. However, adipose-derived stem cells (ASC) have similar immunophenotype, morphology, multilineage potential, and transcriptome compared to BMSC, and both types have demonstrated extensive osteogenic capacity both in vitro and in vivo in several species. The use of scaffolds in combination with stem cells and growth factors provides a valuable tool for guided bone regeneration, especially for complex anatomic defects. Before translation to human medicine, regenerative strategies must be developed in animal models to improve effectiveness and efficiency. The pig presents as a useful model due to similar macro- and microanatomy and favorable logistics of use. This review examines data that provides strong support for the clinical translation of the pig model for bone regeneration.

Original languageEnglish (US)
Pages (from-to)275-287
Number of pages13
JournalAnimal Biotechnology
Volume28
Issue number4
DOIs
StatePublished - Oct 2 2017

Fingerprint

Bone Regeneration
Cell- and Tissue-Based Therapy
Stem cells
Mesenchymal Stromal Cells
stem cells
Bone
Swine
bones
Bone and Bones
therapeutics
swine
Stem Cells
Bone Transplantation
Bone Marrow
Stem Cell Factor
Regenerative Medicine
bone marrow cells
Tissue Engineering
Transcriptome
translation (genetics)

Keywords

  • Bone
  • scaffolds
  • stem cells
  • swine
  • tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Animal Science and Zoology

Cite this

Rubessa, M., Polkoff, K., Bionaz, M., Monaco, E., Milner, D. J., Holllister, S. J., ... Wheeler, M. B. (2017). Use of Pig as a Model for Mesenchymal Stem Cell Therapies for Bone Regeneration. Animal Biotechnology, 28(4), 275-287. https://doi.org/10.1080/10495398.2017.1279169

Use of Pig as a Model for Mesenchymal Stem Cell Therapies for Bone Regeneration. / Rubessa, Marcello; Polkoff, Kathryn; Bionaz, Massimo; Monaco, Elisa; Milner, Derek J.; Holllister, Scott J.; Goldwasser, Michael S.; Wheeler, Matthew B.

In: Animal Biotechnology, Vol. 28, No. 4, 02.10.2017, p. 275-287.

Research output: Contribution to journalReview article

Rubessa, M, Polkoff, K, Bionaz, M, Monaco, E, Milner, DJ, Holllister, SJ, Goldwasser, MS & Wheeler, MB 2017, 'Use of Pig as a Model for Mesenchymal Stem Cell Therapies for Bone Regeneration', Animal Biotechnology, vol. 28, no. 4, pp. 275-287. https://doi.org/10.1080/10495398.2017.1279169
Rubessa M, Polkoff K, Bionaz M, Monaco E, Milner DJ, Holllister SJ et al. Use of Pig as a Model for Mesenchymal Stem Cell Therapies for Bone Regeneration. Animal Biotechnology. 2017 Oct 2;28(4):275-287. https://doi.org/10.1080/10495398.2017.1279169
Rubessa, Marcello ; Polkoff, Kathryn ; Bionaz, Massimo ; Monaco, Elisa ; Milner, Derek J. ; Holllister, Scott J. ; Goldwasser, Michael S. ; Wheeler, Matthew B. / Use of Pig as a Model for Mesenchymal Stem Cell Therapies for Bone Regeneration. In: Animal Biotechnology. 2017 ; Vol. 28, No. 4. pp. 275-287.
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