Use of paramagnetic particles in membrane integrity testing

J. Deluhery, N. Rajagopalan

Research output: Contribution to journalArticlepeer-review


Current online methods of testing membrane integrity - turbidity and particle counting/monitoring - are non-specific and offer moderate sensitivity. An alternative method of probing membrane integrity utilizing magnetically susceptible particles was evaluated as a means to improve both specificity and sensitivity. Compromised 0.6 μm polycarbonate track-etched membranes were challenged with magnetically susceptible particles of 1 μm diameter. Particles that breached the compromised membranes were successfully separated from the filtrate using a particle collector under the influence of a magnetic field. The particle capture efficiency decreased with higher filtrate flow velocity. The captured particles were readily released in the absence of a magnetic field allowing further concentration in a subsequent elution step and increased system sensitivity. Sample calculations show that the proposed technique is a plausible one for large-scale applications.

Original languageEnglish (US)
Pages (from-to)176-181
Number of pages6
JournalJournal of Membrane Science
Issue number1-2
StatePublished - Jun 20 2008


  • Membrane integrity
  • Paramagnetic
  • Test method

ASJC Scopus subject areas

  • Biochemistry
  • General Materials Science
  • Physical and Theoretical Chemistry
  • Filtration and Separation


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