Use of approximate Bayesian computation to assess and fit models of mycobacterium leprae to predict outcomes of the brazilian control program

Rebecca Lee Smith, Yrjö Tapio Gröhn

Research output: Contribution to journalArticle

Abstract

Hansen's disease (leprosy) elimination has proven difficult in several countries, including Brazil, and there is a need for a mathematical model that can predict control program efficacy. This study applied the Approximate Bayesian Computation algorithm to fit 6 different proposed models to each of the 5 regions of Brazil, then fitted hierarchical models based on the best-fit regional models to the entire country. The best model proposed for most regions was a simple model. Posterior checks found that the model results were more similar to the observed incidence after fitting than before, and that parameters varied slightly by region. Current control programs were predicted to require additional measures to eliminate Hansen's Disease as a public health problem in Brazil.

Original languageEnglish (US)
Article numbere0129535
JournalPloS one
Volume10
Issue number6
DOIs
StatePublished - Jun 24 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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