US variant porcine epidemic diarrhea virus: histological lesions and genetic characterization

Leyi Wang, Jeff Hayes, Beverly Byrum, Yan Zhang

Research output: Contribution to journalArticlepeer-review


Porcine epidemic diarrhea virus (PEDV) was first recognized in pigs in the United States (US) in May 2013. Since then, the virus has spread to over 30 states and caused significant economic losses in the US swine industry due to the high mortality in newborn piglets less than 2 weeks of age. A mild-variant strain OH851 of PEDV in the US was first reported in January 2014. Here, we report histological changes in the small intestines of five piglets infected with the variant strain OH851 of PEDV. The lesions observed were milder, compared to the US classical strain of PEDV. Our study, for the first time, reports the histological lesions caused by the variant PEDV OH851 strain from a field case. In addition, genomic characterization demonstrated that US variant PEDV is more closely related to European-like strains in the first 1170 nt of the 5′ spike gene but to US classical PEDV strains in the remaining genome, suggesting that the variant PEDV strain may derive from a recombinant event between the US classical and European-like PEDV strains.

Original languageEnglish (US)
Pages (from-to)578-581
Number of pages4
JournalVirus Genes
Issue number4
StatePublished - Aug 1 2016
Externally publishedYes


  • Genetic characterization
  • Histological lesion
  • PEDV
  • Porcine epidemic diarrhea virus
  • Variant strain

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Virology


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