TY - JOUR
T1 - Update on diagnosis of canine hypothyroidism
AU - Ferguson, D. C.
PY - 1994
Y1 - 1994
N2 - Until a clinically useful canine TSH assay is available, a valid test of thyroid hypofunction should (1) take into consideration valid (or at least predictive) measurement of the free T4 concentration in order to factor out the binding effects of drugs and nonthyroidal illness, and (2) should assess thyroid functional reserve. A validated equilibrium dialysis measurement of free T4 and the TSH stimulation test, provide the most useful diagnostic combination of tests now available. A therapeutic trial with L-thyroxine, despite being relatively safe, should be reserved once other diagnoses have been ruled out, and should be reevaluated to assure a clinical response which can be attributable to the medication.
AB - Until a clinically useful canine TSH assay is available, a valid test of thyroid hypofunction should (1) take into consideration valid (or at least predictive) measurement of the free T4 concentration in order to factor out the binding effects of drugs and nonthyroidal illness, and (2) should assess thyroid functional reserve. A validated equilibrium dialysis measurement of free T4 and the TSH stimulation test, provide the most useful diagnostic combination of tests now available. A therapeutic trial with L-thyroxine, despite being relatively safe, should be reserved once other diagnoses have been ruled out, and should be reevaluated to assure a clinical response which can be attributable to the medication.
UR - http://www.scopus.com/inward/record.url?scp=0028290447&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028290447&partnerID=8YFLogxK
U2 - 10.1016/S0195-5616(94)50057-3
DO - 10.1016/S0195-5616(94)50057-3
M3 - Review article
C2 - 8053111
AN - SCOPUS:0028290447
SN - 0195-5616
VL - 24
SP - 515
EP - 539
JO - Veterinary Clinics of North America - Small Animal Practice
JF - Veterinary Clinics of North America - Small Animal Practice
IS - 3
ER -