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Unveiling the crucial intermediates in androgen production
Piotr J. Mak
, Michael C. Gregory
, Ilia G. Denisov
,
Stephen G. Sligar
, James R. Kincaid
Biochemistry
Chemistry
Research output
:
Contribution to journal
›
Article
›
peer-review
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Keyphrases
17-hydroxypregnenolone
50%
Ablation
50%
Androgen Production
100%
Androgen Synthesis
50%
Androgens
50%
Anions
50%
Bond Cleavage
50%
Carbon-carbon Bond Cleavage
50%
Chemical Transformation
50%
Cytochrome P450 17A1
50%
Dehydroepiandrosterone
50%
Enzymatic Mechanism
50%
Hemiacetal Intermediate
50%
Hydrogen Bond (H-bond)
50%
Hydroxylation
50%
Lyase
100%
Nucleophilic Attack
50%
Peroxo
100%
Pharmaceutical Intervention
50%
Physiological Consequences
50%
Pregnenolone
50%
Primary Substrate
50%
Prostate Cancer
50%
Reaction Intermediates
50%
Structural Characterization
50%
Unveiling
100%
Biochemistry, Genetics and Molecular Biology
17-Hydroxypregnenolone
33%
Anabolism
33%
Androgen Synthesis
100%
Cytochrome P450
33%
Dehydroepiandrosterone
33%
Hydroxylation
33%
Lyase
66%
Nucleophilicity
33%
Pregnenolone
33%
Chemistry
Androgen
100%
Biosynthesis
25%
Catalysis
25%
Chemical Transformation
25%
Cytochrome P450
25%
Dehydroepiandrosterone
25%
Hemiacetal
25%
hydroxylation
25%
Hydroxypregnenolone
25%
Lyase Reaction
25%
Pregnenolone
25%
Reaction Intermediate
25%