Unusual mechanism controls the adhesive failure of bonds between cadherin extracellular domains

Deborah E Leckband, S. Sivasankar, William M Brieher, N. Lavrik, B. Gumbiner

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We examined the forces that control the adhesive behavior of cadherin ectodomains from Xenopus. Using the surface force apparatus, we measured directly the force between oriented, cadherin monolayers as a function of their separation distance. We established previously that cadherin can bind in multiple antiparallel configurations, which involve different regions of the protein. We show that, on account of these interactions, the failure of homophilic cadherin junctions is marked by an unusual unbinding profile that appears to be caused by the hopping between successive minima along the unbinding trajectory. These findings suggest that these multiple adhesive contacts may have evolved in order to impede the abrupt failure of cadherin-mediated cell-cell adhesion.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
ISSN (Print)0589-1019

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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  • Cite this

    Leckband, D. E., Sivasankar, S., Brieher, W. M., Lavrik, N., & Gumbiner, B. (1999). Unusual mechanism controls the adhesive failure of bonds between cadherin extracellular domains. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 2). IEEE.