TY - GEN
T1 - Unusual mechanism controls the adhesive failure of bonds between cadherin extracellular domains
AU - Leckband, D.
AU - Sivasankar, S.
AU - Brieher, W.
AU - Lavrik, N.
AU - Gumbiner, B.
PY - 1999
Y1 - 1999
N2 - We examined the forces that control the adhesive behavior of cadherin ectodomains from Xenopus. Using the surface force apparatus, we measured directly the force between oriented, cadherin monolayers as a function of their separation distance. We established previously that cadherin can bind in multiple antiparallel configurations, which involve different regions of the protein. We show that, on account of these interactions, the failure of homophilic cadherin junctions is marked by an unusual unbinding profile that appears to be caused by the hopping between successive minima along the unbinding trajectory. These findings suggest that these multiple adhesive contacts may have evolved in order to impede the abrupt failure of cadherin-mediated cell-cell adhesion.
AB - We examined the forces that control the adhesive behavior of cadherin ectodomains from Xenopus. Using the surface force apparatus, we measured directly the force between oriented, cadherin monolayers as a function of their separation distance. We established previously that cadherin can bind in multiple antiparallel configurations, which involve different regions of the protein. We show that, on account of these interactions, the failure of homophilic cadherin junctions is marked by an unusual unbinding profile that appears to be caused by the hopping between successive minima along the unbinding trajectory. These findings suggest that these multiple adhesive contacts may have evolved in order to impede the abrupt failure of cadherin-mediated cell-cell adhesion.
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M3 - Conference contribution
AN - SCOPUS:0033348830
SN - 0780356756
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 1342
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PB - IEEE
T2 - Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
Y2 - 13 October 1999 through 16 October 1999
ER -