Unraveling the Global Phylodynamic and Phylogeographic Expansion of Mycoplasma gallisepticum: Understanding the Origin and Expansion of This Pathogen in Ecuador

Laura De la Cruz, Maritza Barrera, Liliam Rios, Belkis Corona-González, Carlos A. Bulnes, Adrian A. Díaz-Sánchez, Jose A. Agüero, Evelyn Lobo-Rivero, Lester J. Pérez

Research output: Contribution to journalArticlepeer-review

Abstract

Mycoplasma gallisepticum (MG) is among the most significant problems in the poultry industry worldwide, representing a serious threat to international trade. Despite the fact that the mgc2 gene has been widely used for diagnostic and molecular characterization purposes, there is a lack of evidence supporting the reliability of this gene as a marker for molecular epidemiology approaches. Therefore, the current study aimed to assess the accuracy of the mgc2 gene for phylogenetic, phylodynamic, and phylogeographic evaluations. Furthermore, the global phylodynamic expansion of MG is described, and the origin and extension of the outbreak caused by MG in Ecuador were tracked and characterized. The results obtained strongly supported the use of the mgc2 gene as a reliable phylogenetic marker and accurate estimator for the temporal and phylogeographic structure reconstruction of MG. The phylodynamic analysis denoted the failures in the current policies to control MG and highlighted the imperative need to implement more sensitive methodologies of diagnosis and more efficient vaccines. Framed in Ecuador, the present study provides the first piece of evidence of the circulation of virulent field MG strains in Ecuadorian commercial poultry. The findings derived from the current study provide novel and significant insights into the origin, diversification, and evolutionary process of MG globally.

Original languageEnglish (US)
Article number0674
Pages (from-to)1-18
Number of pages18
JournalPathogens
Volume9
Issue number9
DOIs
StatePublished - Sep 2020

Keywords

  • Mgc2 gene
  • Mycoplasma gallisepticum
  • Phylodynamic expansion
  • Phylogeographic approach
  • Temporal diversification

ASJC Scopus subject areas

  • Immunology and Allergy
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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