Unlocking nature's biosynthetic potential by directed genome evolution

Mingfeng Cao, Vinh G. Tran, Huimin Zhao

Research output: Contribution to journalReview articlepeer-review


Microorganisms have been increasingly explored as microbial cell factories for production of fuels, chemicals, drugs, and materials. Among the various metabolic engineering strategies, directed genome evolution has emerged as one of the most powerful tools to unlock the full biosynthetic potential of microorganisms. Here we summarize the directed genome evolution strategies that have been developed in recent years, including adaptive laboratory evolution and various targeted genome-scale engineering strategies, and discuss their applications in basic and applied biological research.

Original languageEnglish (US)
Pages (from-to)95-104
Number of pages10
JournalCurrent Opinion in Biotechnology
StatePublished - Dec 2020

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering


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