Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production

Bin Wang; Huimin Zhao

doi:10.1016/j.synbio.2020.01.002

Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Overproduction of polyketides has been a challenge for metabolic engineering for decades. However, recent studies have demonstrated that in both native host and heterologous host, engineering β -oxidation pathways can lead to dramatic improvement of polyketide production.

Original language	English (US)
Pages (from-to)	21-22
Number of pages	2
Journal	Synthetic and Systems Biotechnology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/j.synbio.2020.01.002
State	Published - Mar 2020

Keywords

Beta-oxidation pathway
Metabolic engineering
Polyketide
Triacylglycerols

ASJC Scopus subject areas

Structural Biology
Biomedical Engineering
Applied Microbiology and Biotechnology
Genetics

Online availability

10.1016/j.synbio.2020.01.002

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title = "Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production",

abstract = "Overproduction of polyketides has been a challenge for metabolic engineering for decades. However, recent studies have demonstrated that in both native host and heterologous host, engineering β -oxidation pathways can lead to dramatic improvement of polyketide production.",

keywords = "Beta-oxidation pathway, Metabolic engineering, Polyketide, Triacylglycerols",

author = "Bin Wang and Huimin Zhao",

note = "Funding Information: This work was supported by award AI144967 (to H.Z.) from the U.S. National Institutes of Health (NIH) and awards DE-SC0018260 and DE-SC0018420 (to H.Z.) from the U.S. Department of Energy . Publisher Copyright: {\textcopyright} 2020",

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month = mar,

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language = "English (US)",

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T2 - Engineering β-oxidation pathways for polyketide production

AU - Wang, Bin

AU - Zhao, Huimin

N1 - Funding Information: This work was supported by award AI144967 (to H.Z.) from the U.S. National Institutes of Health (NIH) and awards DE-SC0018260 and DE-SC0018420 (to H.Z.) from the U.S. Department of Energy . Publisher Copyright: © 2020

PY - 2020/3

Y1 - 2020/3

N2 - Overproduction of polyketides has been a challenge for metabolic engineering for decades. However, recent studies have demonstrated that in both native host and heterologous host, engineering β -oxidation pathways can lead to dramatic improvement of polyketide production.

AB - Overproduction of polyketides has been a challenge for metabolic engineering for decades. However, recent studies have demonstrated that in both native host and heterologous host, engineering β -oxidation pathways can lead to dramatic improvement of polyketide production.

KW - Beta-oxidation pathway

KW - Metabolic engineering

KW - Polyketide

KW - Triacylglycerols

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DO - 10.1016/j.synbio.2020.01.002

M3 - Comment/debate

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JO - Synthetic and Systems Biotechnology

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Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production

Abstract

Keywords

ASJC Scopus subject areas

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